Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China
Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnose...
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Wiley
2021-12-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.524 |
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| author | JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu |
| author_facet | JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu |
| author_sort | JiaoJiao Lu |
| collection | DOAJ |
| description | Abstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high‐resolution PCR‐SSP.Exon 2‐3 of HLA‐B*27 gene was amplified and sequenced to further confirm the HLA‐B*27 subtype. Results The frequency of HLA‐B*27 was 99.87% in AS patients. Three subtypes, HLA‐B*2704, HLA‐B*2705, and HLA‐B*2706 were identified. The frequencies for these three alleles were HLA‐B*2704 in 84/88 (95.46%), HLA‐B*2705 in 3/88(3.41%), and HLA‐B*2706 in 1/88 (1.13%) of the HLA‐B*27 positive patients, respectively. Conclusions Our study shows that HLA‐B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA‐B*27‐subtype distributions in Chinese Han populations showed that HLA‐B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA‐B*2705 show the opposite result. |
| format | Article |
| id | doaj-art-b6a430af74ce4015b6abbc8b20b8f832 |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-b6a430af74ce4015b6abbc8b20b8f8322025-08-20T03:15:35ZengWileyImmunity, Inflammation and Disease2050-45272021-12-01941696170110.1002/iid3.524Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern ChinaJiaoJiao Lu0Jing Yang1WenXu Dong2BaoJia Tang3LuoYuan Cao4YingHua Lin5BaoYing Huang6XianGuo Fu7Department of Central Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Central Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Central Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Clinical Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Central Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Traditional Chinese Medicine Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Traditional Chinese Medicine Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaDepartment of Central Laboratory Ningde Municipal Hospital Affiliated to Ningde Normal University Ningde Fujian ChinaAbstract Objectives This study was to investigate the polymorphism and distribution of alleles of HLA‐B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. Methods A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high‐resolution PCR‐SSP.Exon 2‐3 of HLA‐B*27 gene was amplified and sequenced to further confirm the HLA‐B*27 subtype. Results The frequency of HLA‐B*27 was 99.87% in AS patients. Three subtypes, HLA‐B*2704, HLA‐B*2705, and HLA‐B*2706 were identified. The frequencies for these three alleles were HLA‐B*2704 in 84/88 (95.46%), HLA‐B*2705 in 3/88(3.41%), and HLA‐B*2706 in 1/88 (1.13%) of the HLA‐B*27 positive patients, respectively. Conclusions Our study shows that HLA‐B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA‐B*27‐subtype distributions in Chinese Han populations showed that HLA‐B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA‐B*2705 show the opposite result.https://doi.org/10.1002/iid3.524ankylosing spondylitishigh‐resolution PCR‐SSPHLA‐B*27subtypes |
| spellingShingle | JiaoJiao Lu Jing Yang WenXu Dong BaoJia Tang LuoYuan Cao YingHua Lin BaoYing Huang XianGuo Fu Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China Immunity, Inflammation and Disease ankylosing spondylitis high‐resolution PCR‐SSP HLA‐B*27 subtypes |
| title | Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China |
| title_full | Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China |
| title_fullStr | Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China |
| title_full_unstemmed | Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China |
| title_short | Predominant frequency of HLA‐B*27 in patients with ankylosing spondylitis in southeastern China |
| title_sort | predominant frequency of hla b 27 in patients with ankylosing spondylitis in southeastern china |
| topic | ankylosing spondylitis high‐resolution PCR‐SSP HLA‐B*27 subtypes |
| url | https://doi.org/10.1002/iid3.524 |
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