Divergence in a eukaryotic transcription factor’s co-TF dependence involves multiple intrinsically disordered regions

Divergence in a eukaryotic transcription factor’s co-TF dependence involves multiple intrinsically disordered regions

Abstract Combinatorial control by transcription factors (TFs) is central to eukaryotic gene regulation, yet its mechanism, evolution, and regulatory impact are not well understood. Here we use natural variation in the yeast phosphate starvation (PHO) response to examine the genetic basis and species...

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Main Authors: Lindsey F. Snyder, Emily M. O’Brien, Jia Zhao, Jinye Liang, Baylee J. Bruce, Yuning Zhang, Wei Zhu, Thomas H. Cassier, Nicholas J. Schnicker, Xu Zhou, Raluca Gordân, Bin Z. He
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59244-w
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