Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease
Background. Assessment of endoscopic activity of Crohn’s disease (CD) is of growing importance both in clinical practice and in clinical trials. The study aimed to assess which of the endoscopic indices used for evaluation of mucosal changes correlates with the currently used clinical indices for de...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7896478 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849395872107855872 |
|---|---|
| author | Marcin Kucharski Jacek Karczewski Dorota Mańkowska-Wierzbicka Katarzyna Karmelita-Katulska Elżbieta Kaczmarek Katarzyna Iwanik Piotr Rzymski Marian Grzymisławski Krzysztof Linke Agnieszka Dobrowolska |
| author_facet | Marcin Kucharski Jacek Karczewski Dorota Mańkowska-Wierzbicka Katarzyna Karmelita-Katulska Elżbieta Kaczmarek Katarzyna Iwanik Piotr Rzymski Marian Grzymisławski Krzysztof Linke Agnieszka Dobrowolska |
| author_sort | Marcin Kucharski |
| collection | DOAJ |
| description | Background. Assessment of endoscopic activity of Crohn’s disease (CD) is of growing importance both in clinical practice and in clinical trials. The study aimed to assess which of the endoscopic indices used for evaluation of mucosal changes correlates with the currently used clinical indices for determination of disease activity and with the results of histopathological examination. Study. A group of 71 patients with CD and 52 individuals without a diagnosis of GI tract disease as a control group were investigated, considering clinical and histological severity of the disease and the severity of inflammatory changes in the bowel. Evaluation was conducted with the use of clinical, endoscopic, and histopathological indices. Endoscopic indices were then correlated with different clinical and histopathological indices with the aim of finding the strongest correlations. Results and Conclusions. Correlation between the clinical disease activity and the severity of endoscopic lesions in CD was shown in this study to be poor. The results also indicate that the optimal endoscopic index used in the diagnostic stage and in the assessment of treatment effects in CD is Simple Endoscopic Score for Crohn’s Disease (SES-CD). |
| format | Article |
| id | doaj-art-b6a2723e5e164808a2793e433f25edb9 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b6a2723e5e164808a2793e433f25edb92025-08-20T03:39:29ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/78964787896478Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s DiseaseMarcin Kucharski0Jacek Karczewski1Dorota Mańkowska-Wierzbicka2Katarzyna Karmelita-Katulska3Elżbieta Kaczmarek4Katarzyna Iwanik5Piotr Rzymski6Marian Grzymisławski7Krzysztof Linke8Agnieszka Dobrowolska9Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandDepartment of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandPoznan University of Medical Sciences, Fredry 10, 61-701 Poznań, PolandDepartment of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355 Poznań, PolandBackground. Assessment of endoscopic activity of Crohn’s disease (CD) is of growing importance both in clinical practice and in clinical trials. The study aimed to assess which of the endoscopic indices used for evaluation of mucosal changes correlates with the currently used clinical indices for determination of disease activity and with the results of histopathological examination. Study. A group of 71 patients with CD and 52 individuals without a diagnosis of GI tract disease as a control group were investigated, considering clinical and histological severity of the disease and the severity of inflammatory changes in the bowel. Evaluation was conducted with the use of clinical, endoscopic, and histopathological indices. Endoscopic indices were then correlated with different clinical and histopathological indices with the aim of finding the strongest correlations. Results and Conclusions. Correlation between the clinical disease activity and the severity of endoscopic lesions in CD was shown in this study to be poor. The results also indicate that the optimal endoscopic index used in the diagnostic stage and in the assessment of treatment effects in CD is Simple Endoscopic Score for Crohn’s Disease (SES-CD).http://dx.doi.org/10.1155/2016/7896478 |
| spellingShingle | Marcin Kucharski Jacek Karczewski Dorota Mańkowska-Wierzbicka Katarzyna Karmelita-Katulska Elżbieta Kaczmarek Katarzyna Iwanik Piotr Rzymski Marian Grzymisławski Krzysztof Linke Agnieszka Dobrowolska Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease Gastroenterology Research and Practice |
| title | Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease |
| title_full | Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease |
| title_fullStr | Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease |
| title_full_unstemmed | Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease |
| title_short | Usefulness of Endoscopic Indices in Determination of Disease Activity in Patients with Crohn’s Disease |
| title_sort | usefulness of endoscopic indices in determination of disease activity in patients with crohn s disease |
| url | http://dx.doi.org/10.1155/2016/7896478 |
| work_keys_str_mv | AT marcinkucharski usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT jacekkarczewski usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT dorotamankowskawierzbicka usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT katarzynakarmelitakatulska usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT elzbietakaczmarek usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT katarzynaiwanik usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT piotrrzymski usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT mariangrzymisławski usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT krzysztoflinke usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease AT agnieszkadobrowolska usefulnessofendoscopicindicesindeterminationofdiseaseactivityinpatientswithcrohnsdisease |