Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity
AimsAtrial fibrillation (AF) is associated with cognitive decline, but the role of electroencephalography (EEG) in assessing cognitive dysfunction in AF patients is underexplored.ObjectiveThis study investigated the relationship between resting-state EEG patterns and cognitive impairment in AF patie...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1583715/full |
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| author | Min-qiang Bao Min-qiang Bao Li Cao Yi-nong Chen Guo-liang Gao Zhi-yong Lu Jie Wang Shuang-shuang Chen Xiao-ning Sheng Yu Wang |
| author_facet | Min-qiang Bao Min-qiang Bao Li Cao Yi-nong Chen Guo-liang Gao Zhi-yong Lu Jie Wang Shuang-shuang Chen Xiao-ning Sheng Yu Wang |
| author_sort | Min-qiang Bao |
| collection | DOAJ |
| description | AimsAtrial fibrillation (AF) is associated with cognitive decline, but the role of electroencephalography (EEG) in assessing cognitive dysfunction in AF patients is underexplored.ObjectiveThis study investigated the relationship between resting-state EEG patterns and cognitive impairment in AF patients.MethodsWe recruited 120 participants from the Affiliated Xuancheng Hospital, China (January 2023 to January 2024), categorizing them into healthy controls and AF patients. Resting-state EEG metrics, including power spectral density (PSD), functional connectivity (FC), cross-frequency coupling (CFC), and sample entropy (EnSA), were analyzed alongside the Montreal Cognitive Assessment (MoCA) scores. Mediation analysis explored EEG's role in the AF-cognitive decline relationship.ResultsAF patients had significantly lower MoCA scores. PSD analysis showed increased δ and θ and decreased α and β activity. FC was reduced in the α and β bands but increased in localized θ and γ bands. CFC analysis revealed elevated θ–β and θ–γ phase-amplitude coupling (PAC), reduced β–γ PAC, and lower EnSA. EEG metrics were significantly correlated with MoCA scores, with θ–β PAC mediating cognitive decline.ConclusionAF patients exhibit distinctive EEG changes, with θ–β PAC mediating cognitive impairment, suggesting the potential of resting-state EEG for cognitive assessment in AF patients. |
| format | Article |
| id | doaj-art-b6a24e5fd7e649faa301d839adf9653e |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-b6a24e5fd7e649faa301d839adf9653e2025-08-20T02:36:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15837151583715Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivityMin-qiang Bao0Min-qiang Bao1Li Cao2Yi-nong Chen3Guo-liang Gao4Zhi-yong Lu5Jie Wang6Shuang-shuang Chen7Xiao-ning Sheng8Yu Wang9Department of Neurology, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Electrocardiogram, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Electrocardiogram, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Cardiovascular Medicine, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Neurology, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Neurology, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Neurology, The Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaAimsAtrial fibrillation (AF) is associated with cognitive decline, but the role of electroencephalography (EEG) in assessing cognitive dysfunction in AF patients is underexplored.ObjectiveThis study investigated the relationship between resting-state EEG patterns and cognitive impairment in AF patients.MethodsWe recruited 120 participants from the Affiliated Xuancheng Hospital, China (January 2023 to January 2024), categorizing them into healthy controls and AF patients. Resting-state EEG metrics, including power spectral density (PSD), functional connectivity (FC), cross-frequency coupling (CFC), and sample entropy (EnSA), were analyzed alongside the Montreal Cognitive Assessment (MoCA) scores. Mediation analysis explored EEG's role in the AF-cognitive decline relationship.ResultsAF patients had significantly lower MoCA scores. PSD analysis showed increased δ and θ and decreased α and β activity. FC was reduced in the α and β bands but increased in localized θ and γ bands. CFC analysis revealed elevated θ–β and θ–γ phase-amplitude coupling (PAC), reduced β–γ PAC, and lower EnSA. EEG metrics were significantly correlated with MoCA scores, with θ–β PAC mediating cognitive decline.ConclusionAF patients exhibit distinctive EEG changes, with θ–β PAC mediating cognitive impairment, suggesting the potential of resting-state EEG for cognitive assessment in AF patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1583715/fullatrial fibrillationcognitive dysfunctionresting-state EEGpower spectral densityfunctional connectivitycross-frequency coupling |
| spellingShingle | Min-qiang Bao Min-qiang Bao Li Cao Yi-nong Chen Guo-liang Gao Zhi-yong Lu Jie Wang Shuang-shuang Chen Xiao-ning Sheng Yu Wang Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity Frontiers in Neurology atrial fibrillation cognitive dysfunction resting-state EEG power spectral density functional connectivity cross-frequency coupling |
| title | Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity |
| title_full | Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity |
| title_fullStr | Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity |
| title_full_unstemmed | Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity |
| title_short | Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity |
| title_sort | resting state eeg alterations and cognitive impairment in atrial fibrillation insights into neural biomarkers and functional connectivity |
| topic | atrial fibrillation cognitive dysfunction resting-state EEG power spectral density functional connectivity cross-frequency coupling |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1583715/full |
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