Hypoxia Promotes the In Vitro Proliferation of Buffalo Spermatogonial Cells by Increasing Lactate and H3K18la Lactylation Levels

Hypoxia Promotes the In Vitro Proliferation of Buffalo Spermatogonial Cells by Increasing Lactate and H3K18la Lactylation Levels

Hypoxia benefits the proliferation and maintenance of animal spermatogonial cells; however, the underlying mechanism remains incompletely understood. This study aims to investigate the role and mechanism of the hypoxia–glycolysis–histone lactylation axis in the proliferation of buffalo spermatogonia...

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Bibliographic Details
Main Authors: Mengqi Li, Yanyu Ma, Shenzhi Wang, Haiying Zheng, Chunyan Yang, Anqin Duan, Benliang Zhou, Jianghua Shang, Xingwei Liang, Xiaogan Yang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
spermatogonial cells
hypoxia
proliferation
histone lactylation
buffalo
Online Access:https://www.mdpi.com/2073-4409/14/11/832
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