Anti-Inflammatory Compounds from Vietnamese Piper bavinum
This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/1038636 |
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| author | Viet Dung Hoang Phi Hung Nguyen Minh Thu Doan Manh Hung Tran Nhu Tuan Huynh Huu Tung Nguyen Byung Sun Min Dao Cuong To |
| author_facet | Viet Dung Hoang Phi Hung Nguyen Minh Thu Doan Manh Hung Tran Nhu Tuan Huynh Huu Tung Nguyen Byung Sun Min Dao Cuong To |
| author_sort | Viet Dung Hoang |
| collection | DOAJ |
| description | This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from P. bavinum for the first time. All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro. Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM. In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner. The results suggested that P. bavinum and its constituents might exert anti-inflammatory effects. |
| format | Article |
| id | doaj-art-b6a1a00718c041acb734a2b04f355e8a |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b6a1a00718c041acb734a2b04f355e8a2025-08-20T03:39:29ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/10386361038636Anti-Inflammatory Compounds from Vietnamese Piper bavinumViet Dung Hoang0Phi Hung Nguyen1Minh Thu Doan2Manh Hung Tran3Nhu Tuan Huynh4Huu Tung Nguyen5Byung Sun Min6Dao Cuong To7Institute of Pharmaceutical Training, Vietnam Military Medical University, 160 Phung Hung Street, Hadong District, Hanoi 151000, VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, VietnamDepartment of Biomedical Sciences, Institute for Research and Executive Education (VNUK), The University of Danang, 158A Le Loi Street, Hai Chau District, Da Nang 551000, VietnamDepartment of Biomedical Sciences, Institute for Research and Executive Education (VNUK), The University of Danang, 158A Le Loi Street, Hai Chau District, Da Nang 551000, VietnamFaculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hai Chau District, Da Nang 550000, VietnamFaculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, VietnamCollege of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongsan 712–702, Republic of KoreaFaculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, VietnamThis study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from P. bavinum for the first time. All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro. Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM. In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner. The results suggested that P. bavinum and its constituents might exert anti-inflammatory effects.http://dx.doi.org/10.1155/2020/1038636 |
| spellingShingle | Viet Dung Hoang Phi Hung Nguyen Minh Thu Doan Manh Hung Tran Nhu Tuan Huynh Huu Tung Nguyen Byung Sun Min Dao Cuong To Anti-Inflammatory Compounds from Vietnamese Piper bavinum Journal of Chemistry |
| title | Anti-Inflammatory Compounds from Vietnamese Piper bavinum |
| title_full | Anti-Inflammatory Compounds from Vietnamese Piper bavinum |
| title_fullStr | Anti-Inflammatory Compounds from Vietnamese Piper bavinum |
| title_full_unstemmed | Anti-Inflammatory Compounds from Vietnamese Piper bavinum |
| title_short | Anti-Inflammatory Compounds from Vietnamese Piper bavinum |
| title_sort | anti inflammatory compounds from vietnamese piper bavinum |
| url | http://dx.doi.org/10.1155/2020/1038636 |
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