Effect of docetaxel administration on fluid dynamics in mice
Objectives: The taxane chemotherapeutic agent docetaxel has been used as a therapy for various cancers. Some patients receiving docetaxel develop serious problems with fluid retention, which leads to peripheral edema formation, reducing the patient’s quality of life. This study investigated the effe...
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| Language: | English |
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Fujita Medical Society
2025-05-01
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| Series: | Fujita Medical Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/fmj/11/2/11_2024-023/_pdf/-char/ja |
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| author | Ayana Mawaki Masushi Kohta Aya Yoshimura Toshio Nakatani Shizuko Nagao Junko Sugama |
| author_facet | Ayana Mawaki Masushi Kohta Aya Yoshimura Toshio Nakatani Shizuko Nagao Junko Sugama |
| author_sort | Ayana Mawaki |
| collection | DOAJ |
| description | Objectives: The taxane chemotherapeutic agent docetaxel has been used as a therapy for various cancers. Some patients receiving docetaxel develop serious problems with fluid retention, which leads to peripheral edema formation, reducing the patient’s quality of life. This study investigated the effect of docetaxel administration on fluid dynamics in mice as a step toward developing advanced preventive measures in nursing.
Methods: Mice were administered 10 mg/kg/day of docetaxel intravenously for 5 days as the intervention group or with normal saline as the control group. To investigate fluid dynamics on day 5, the leakage of blood plasma, interstitial fluid volume, and fluid transportation capacity into lymph vessels were evaluated and compared between the two groups.
Results: The Miles assay with Evans Blue, an albumin-binding dye, revealed that leakage of blood plasma was significantly increased in the control group compared with the intervention group (p<0.01). Results of the interstitial fluid volume and fluid transportation capacity were similar between the two groups, but the fluid transportation capacity tended to be higher in the intervention group.
Conclusions: Docetaxel administration in our mouse model caused the leakage of blood plasma without proteins from the blood vessels into the interstitial tissues, which appeared at the initial stage of edema formation. This model might be useful for assessing the leakage of blood plasma and, subsequently, the development of preventive measures against edema formation. |
| format | Article |
| id | doaj-art-b69cf8d480dd49d7bdd972834f5d8eee |
| institution | DOAJ |
| issn | 2189-7247 2189-7255 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Fujita Medical Society |
| record_format | Article |
| series | Fujita Medical Journal |
| spelling | doaj-art-b69cf8d480dd49d7bdd972834f5d8eee2025-08-20T02:56:23ZengFujita Medical SocietyFujita Medical Journal2189-72472189-72552025-05-011125963https://doi.org/10.20407/fmj.2024-023Effect of docetaxel administration on fluid dynamics in miceAyana Mawaki0Masushi Kohta1Aya Yoshimura2Toshio Nakatani3Shizuko Nagao4Junko Sugama5Graduate School of Health Sciences, Fujita Health University; Department of Integrated Health Sciences, Nagoya University Graduate School of MedicineResearch Center for Implementation Nursing Science Initiative, Fujita Health UniversityAdvanced Medical Research Center for Animal Models of Human Diseases, Fujita Health UniversityDepartment of Nutrition, Faculty of Health Science, Hokuriku Gakuin UniversityAdvanced Medical Research Center for Animal Models of Human Diseases, Fujita Health UniversityResearch Center for Implementation Nursing Science Initiative, Fujita Health UniversityObjectives: The taxane chemotherapeutic agent docetaxel has been used as a therapy for various cancers. Some patients receiving docetaxel develop serious problems with fluid retention, which leads to peripheral edema formation, reducing the patient’s quality of life. This study investigated the effect of docetaxel administration on fluid dynamics in mice as a step toward developing advanced preventive measures in nursing. Methods: Mice were administered 10 mg/kg/day of docetaxel intravenously for 5 days as the intervention group or with normal saline as the control group. To investigate fluid dynamics on day 5, the leakage of blood plasma, interstitial fluid volume, and fluid transportation capacity into lymph vessels were evaluated and compared between the two groups. Results: The Miles assay with Evans Blue, an albumin-binding dye, revealed that leakage of blood plasma was significantly increased in the control group compared with the intervention group (p<0.01). Results of the interstitial fluid volume and fluid transportation capacity were similar between the two groups, but the fluid transportation capacity tended to be higher in the intervention group. Conclusions: Docetaxel administration in our mouse model caused the leakage of blood plasma without proteins from the blood vessels into the interstitial tissues, which appeared at the initial stage of edema formation. This model might be useful for assessing the leakage of blood plasma and, subsequently, the development of preventive measures against edema formation.https://www.jstage.jst.go.jp/article/fmj/11/2/11_2024-023/_pdf/-char/jadocetaxeledema formationfluid dynamicsmice |
| spellingShingle | Ayana Mawaki Masushi Kohta Aya Yoshimura Toshio Nakatani Shizuko Nagao Junko Sugama Effect of docetaxel administration on fluid dynamics in mice Fujita Medical Journal docetaxel edema formation fluid dynamics mice |
| title | Effect of docetaxel administration on fluid dynamics in mice |
| title_full | Effect of docetaxel administration on fluid dynamics in mice |
| title_fullStr | Effect of docetaxel administration on fluid dynamics in mice |
| title_full_unstemmed | Effect of docetaxel administration on fluid dynamics in mice |
| title_short | Effect of docetaxel administration on fluid dynamics in mice |
| title_sort | effect of docetaxel administration on fluid dynamics in mice |
| topic | docetaxel edema formation fluid dynamics mice |
| url | https://www.jstage.jst.go.jp/article/fmj/11/2/11_2024-023/_pdf/-char/ja |
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