Congenital Defects in Neutrophil Dynamics
Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their ar...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/303782 |
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| _version_ | 1832567613346021376 |
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| author | Marton Keszei Lisa S. Westerberg |
| author_facet | Marton Keszei Lisa S. Westerberg |
| author_sort | Marton Keszei |
| collection | DOAJ |
| description | Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion. |
| format | Article |
| id | doaj-art-b69b5b833e8d4351bcae6d72353a7d00 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b69b5b833e8d4351bcae6d72353a7d002025-02-03T01:01:09ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/303782303782Congenital Defects in Neutrophil DynamicsMarton Keszei0Lisa S. Westerberg1Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Microbiology Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, SwedenNeutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion.http://dx.doi.org/10.1155/2014/303782 |
| spellingShingle | Marton Keszei Lisa S. Westerberg Congenital Defects in Neutrophil Dynamics Journal of Immunology Research |
| title | Congenital Defects in Neutrophil Dynamics |
| title_full | Congenital Defects in Neutrophil Dynamics |
| title_fullStr | Congenital Defects in Neutrophil Dynamics |
| title_full_unstemmed | Congenital Defects in Neutrophil Dynamics |
| title_short | Congenital Defects in Neutrophil Dynamics |
| title_sort | congenital defects in neutrophil dynamics |
| url | http://dx.doi.org/10.1155/2014/303782 |
| work_keys_str_mv | AT martonkeszei congenitaldefectsinneutrophildynamics AT lisaswesterberg congenitaldefectsinneutrophildynamics |