The potential of cell therapy in the treatment of univentricular heart defects
The single ventricle is a group of congenital heart defects, which even today remains the most difficult for surgical treatment and further patient care. The survival rate of patients with this defect remains relatively low despite a number of staged surgical interventions. A large percentage of mor...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2024-10-01
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| Series: | Вестник хирургии имени И.И. Грекова |
| Subjects: | |
| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/2369 |
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| _version_ | 1849340763044839424 |
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| author | A. V. Nokhrin A. V. Amosova I. A. Cherepakhina G. B. Belostotskaya E. S. Kulemin D. O. Ivanov |
| author_facet | A. V. Nokhrin A. V. Amosova I. A. Cherepakhina G. B. Belostotskaya E. S. Kulemin D. O. Ivanov |
| author_sort | A. V. Nokhrin |
| collection | DOAJ |
| description | The single ventricle is a group of congenital heart defects, which even today remains the most difficult for surgical treatment and further patient care. The survival rate of patients with this defect remains relatively low despite a number of staged surgical interventions. A large percentage of mortality is observed in the interstage period due to the development of heart failure, the treatment of which is an urgent problem because standard therapy does not meet expectations. This article reviews the world literature on the application of an innovative method of heart failure correction – stem cell therapy. The main types of stem cells, their sources, mechanism of action, methods of their delivery to myocardium are also considered. |
| format | Article |
| id | doaj-art-b6945ad026354918a4dbd778a7d8388d |
| institution | Kabale University |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-b6945ad026354918a4dbd778a7d8388d2025-08-20T03:43:48ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252024-10-011833748110.24884/0042-4625-2024-183-3-74-811614The potential of cell therapy in the treatment of univentricular heart defectsA. V. Nokhrin0A. V. Amosova1I. A. Cherepakhina2G. B. Belostotskaya3E. S. Kulemin4D. O. Ivanov5Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg State Pediatric Medical UniversitySaint-Petersburg State Pediatric Medical UniversityI. M Sechenov Institute of Evolutionary Physiology and BiochemistrySaint-Petersburg State Pediatric Medical UniversitySaint-Petersburg State Pediatric Medical UniversityThe single ventricle is a group of congenital heart defects, which even today remains the most difficult for surgical treatment and further patient care. The survival rate of patients with this defect remains relatively low despite a number of staged surgical interventions. A large percentage of mortality is observed in the interstage period due to the development of heart failure, the treatment of which is an urgent problem because standard therapy does not meet expectations. This article reviews the world literature on the application of an innovative method of heart failure correction – stem cell therapy. The main types of stem cells, their sources, mechanism of action, methods of their delivery to myocardium are also considered.https://www.vestnik-grekova.ru/jour/article/view/2369congenital heart diseasesingle ventriclestem cells therapystem cellsnorwood procedurefontan operation |
| spellingShingle | A. V. Nokhrin A. V. Amosova I. A. Cherepakhina G. B. Belostotskaya E. S. Kulemin D. O. Ivanov The potential of cell therapy in the treatment of univentricular heart defects Вестник хирургии имени И.И. Грекова congenital heart disease single ventricle stem cells therapy stem cells norwood procedure fontan operation |
| title | The potential of cell therapy in the treatment of univentricular heart defects |
| title_full | The potential of cell therapy in the treatment of univentricular heart defects |
| title_fullStr | The potential of cell therapy in the treatment of univentricular heart defects |
| title_full_unstemmed | The potential of cell therapy in the treatment of univentricular heart defects |
| title_short | The potential of cell therapy in the treatment of univentricular heart defects |
| title_sort | potential of cell therapy in the treatment of univentricular heart defects |
| topic | congenital heart disease single ventricle stem cells therapy stem cells norwood procedure fontan operation |
| url | https://www.vestnik-grekova.ru/jour/article/view/2369 |
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