The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis
Aims: Major Depressive Disorder (MDD) is a leading global health concern, significantly impacting quality of life. Conventional treatments like antidepressants are effective but not universally successful, prompting interest in adjunctive therapies. Omega-3 fatty acids, particularly eicosapentaenoic...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425101476/type/journal_article |
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| author | Oluwatobi Idowu Nicholas Aderinto Gbolahan Olatunji Emmanuel Kokori |
| author_facet | Oluwatobi Idowu Nicholas Aderinto Gbolahan Olatunji Emmanuel Kokori |
| author_sort | Oluwatobi Idowu |
| collection | DOAJ |
| description | Aims: Major Depressive Disorder (MDD) is a leading global health concern, significantly impacting quality of life. Conventional treatments like antidepressants are effective but not universally successful, prompting interest in adjunctive therapies. Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are thought to offer neuroprotective and anti-inflammatory benefits that may help manage MDD. This systematic review and meta-analysis assessed the efficacy of omega-3 supplementation in reducing depressive symptoms, improving remission rates, and enhancing overall treatment outcomes in adults with MDD. |
| format | Article |
| id | doaj-art-b692e09314194ea4bf5d8ed03509e692 |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-b692e09314194ea4bf5d8ed03509e6922025-08-20T03:32:54ZengCambridge University PressBJPsych Open2056-47242025-06-0111S43S4410.1192/bjo.2025.10147The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-AnalysisOluwatobi Idowu0Nicholas Aderinto1Gbolahan Olatunji2Emmanuel Kokori3Cheshire and Wirral Partnership NHS Foundation Trust, Chester, United KingdomDepartment of Medicine, Ladoke Akintola University of Technology, Ogbomoso, NigeriaDepartment of Medicine and Surgery, University of Ilorin, Ilorin, NigeriaDepartment of Medicine and Surgery, University of Ilorin, Ilorin, NigeriaAims: Major Depressive Disorder (MDD) is a leading global health concern, significantly impacting quality of life. Conventional treatments like antidepressants are effective but not universally successful, prompting interest in adjunctive therapies. Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are thought to offer neuroprotective and anti-inflammatory benefits that may help manage MDD. This systematic review and meta-analysis assessed the efficacy of omega-3 supplementation in reducing depressive symptoms, improving remission rates, and enhancing overall treatment outcomes in adults with MDD.https://www.cambridge.org/core/product/identifier/S2056472425101476/type/journal_article |
| spellingShingle | Oluwatobi Idowu Nicholas Aderinto Gbolahan Olatunji Emmanuel Kokori The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis BJPsych Open |
| title | The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis |
| title_full | The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis |
| title_fullStr | The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis |
| title_short | The Efficacy of Omega-3 Fatty Acid Supplementation for Major Depressive Disorder in Adults: A Systematic Review and Meta-Analysis |
| title_sort | efficacy of omega 3 fatty acid supplementation for major depressive disorder in adults a systematic review and meta analysis |
| url | https://www.cambridge.org/core/product/identifier/S2056472425101476/type/journal_article |
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