Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population
ABSTRACT Background Although the gut microbiota is associated with type 2 diabetes (T2D) and its remission in clinical settings, their relationship in the general population remains unclear. This study aimed to investigate the association between the gut microbiota and T2D and its remission in a pop...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70061 |
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| author | Keita Kinoshita Naoki Ozato Tohru Yamaguchi Kenta Mori Yoshihisa Katsuragi Noriaki Sato Seiya Imoto Kazushige Ihara Koichi Murashita Shigeyuki Nakaji Tatsuya Mikami |
| author_facet | Keita Kinoshita Naoki Ozato Tohru Yamaguchi Kenta Mori Yoshihisa Katsuragi Noriaki Sato Seiya Imoto Kazushige Ihara Koichi Murashita Shigeyuki Nakaji Tatsuya Mikami |
| author_sort | Keita Kinoshita |
| collection | DOAJ |
| description | ABSTRACT Background Although the gut microbiota is associated with type 2 diabetes (T2D) and its remission in clinical settings, their relationship in the general population remains unclear. This study aimed to investigate the association between the gut microbiota and T2D and its remission in a population‐based setting. Methods A cross‐sectional study was conducted on 1,639 Japanese participants with (n = 106) or without (n = 1,533) T2D. The gut microbiota was compared between the two groups using multivariable‐adjusted logistic regression. The relative abundance of the gut microbiota in fecal samples was calculated using 16S ribosomal RNA amplification. The association between the gut microbiota and T2D remission was determined via longitudinal analyses. Results Six genera were independently associated with T2D; a higher abundance of Faecalibacterium, Blautia, Roseburia, and Oscillibacter was significantly associated with a lower odds ratio for T2D, whereas a higher abundance of Megasphaera and Lactobacillus was significantly associated with a higher odds ratio for T2D. Of these, only Blautia abundance was significantly increased in the remission group compared with that in the non‐remission group. In the remission group, an increase in Blautia abundance was significantly correlated with an increase in adiponectin level and skeletal muscle mass. Conclusions Specific gut microbes were significantly associated with T2D and its remission. The gut microbiota may represent a potential area for further exploration in T2D treatment and prevention. However, additional large‐scale cohort studies or intervention studies using a probiotic or prebiotic approach are needed to validate these findings. |
| format | Article |
| id | doaj-art-b68e9e5e4e64456580a219c38607987a |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-b68e9e5e4e64456580a219c38607987a2025-08-20T03:29:52ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-07-011671315132410.1111/jdi.70061Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese populationKeita Kinoshita0Naoki Ozato1Tohru Yamaguchi2Kenta Mori3Yoshihisa Katsuragi4Noriaki Sato5Seiya Imoto6Kazushige Ihara7Koichi Murashita8Shigeyuki Nakaji9Tatsuya Mikami10Department of Active Life Promotion Sciences Hirosaki University Graduate School of Medicine Aomori JapanDepartment of Active Life Promotion Sciences Hirosaki University Graduate School of Medicine Aomori JapanHuman Health Care Products Research Laboratories Kao Corporation Tokyo JapanDepartment of Active Life Promotion Sciences Hirosaki University Graduate School of Medicine Aomori JapanDepartment of Active Life Promotion Sciences Hirosaki University Graduate School of Medicine Aomori JapanHuman Genome Center, Institute of Medical Science University of Tokyo Tokyo JapanHuman Genome Center, Institute of Medical Science University of Tokyo Tokyo JapanDepartment of Social Medicine Hirosaki University Graduate School of Medicine Aomori JapanResearch Institute of Health Innovation Hirosaki University Aomori JapanDepartment of Social Medicine Hirosaki University Graduate School of Medicine Aomori JapanInnovation Center for Health Promotion Hirosaki University Graduate School of Medicine Aomori JapanABSTRACT Background Although the gut microbiota is associated with type 2 diabetes (T2D) and its remission in clinical settings, their relationship in the general population remains unclear. This study aimed to investigate the association between the gut microbiota and T2D and its remission in a population‐based setting. Methods A cross‐sectional study was conducted on 1,639 Japanese participants with (n = 106) or without (n = 1,533) T2D. The gut microbiota was compared between the two groups using multivariable‐adjusted logistic regression. The relative abundance of the gut microbiota in fecal samples was calculated using 16S ribosomal RNA amplification. The association between the gut microbiota and T2D remission was determined via longitudinal analyses. Results Six genera were independently associated with T2D; a higher abundance of Faecalibacterium, Blautia, Roseburia, and Oscillibacter was significantly associated with a lower odds ratio for T2D, whereas a higher abundance of Megasphaera and Lactobacillus was significantly associated with a higher odds ratio for T2D. Of these, only Blautia abundance was significantly increased in the remission group compared with that in the non‐remission group. In the remission group, an increase in Blautia abundance was significantly correlated with an increase in adiponectin level and skeletal muscle mass. Conclusions Specific gut microbes were significantly associated with T2D and its remission. The gut microbiota may represent a potential area for further exploration in T2D treatment and prevention. However, additional large‐scale cohort studies or intervention studies using a probiotic or prebiotic approach are needed to validate these findings.https://doi.org/10.1111/jdi.70061Gut microbiotaRemissionType 2 diabetes |
| spellingShingle | Keita Kinoshita Naoki Ozato Tohru Yamaguchi Kenta Mori Yoshihisa Katsuragi Noriaki Sato Seiya Imoto Kazushige Ihara Koichi Murashita Shigeyuki Nakaji Tatsuya Mikami Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population Journal of Diabetes Investigation Gut microbiota Remission Type 2 diabetes |
| title | Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population |
| title_full | Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population |
| title_fullStr | Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population |
| title_full_unstemmed | Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population |
| title_short | Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population |
| title_sort | association of the gut microbiota with type 2 diabetes links to disease and remission in the japanese population |
| topic | Gut microbiota Remission Type 2 diabetes |
| url | https://doi.org/10.1111/jdi.70061 |
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