Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura
We report a case of a 66-year-old African-American female who presented with complaints of progressively worsening weakness, shortness of breath on minimal exertion, lethargy for the last few days, and short episodes of aphasia lasting 20–30 seconds. Prior to presentation, she was treated with two c...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/459140 |
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| author | Sikander P. Surana Zahily Sardinas Alan S. Multz |
| author_facet | Sikander P. Surana Zahily Sardinas Alan S. Multz |
| author_sort | Sikander P. Surana |
| collection | DOAJ |
| description | We report a case of a 66-year-old African-American female who presented with complaints of progressively worsening weakness, shortness of breath on minimal exertion, lethargy for the last few days, and short episodes of aphasia lasting 20–30 seconds. Prior to presentation, she was treated with two courses of moxifloxacin for sinusitis. Laboratory examination was remarkable for anemia and thrombocytopenia with elevated lactate dehydrogenase and no evidence of renal failure. Peripheral smear showed numerous schistocytes and she was diagnosed with thrombotic thrombocytopenic purpura. Moxifloxacin was identified as the offending agent. The patient was treated with prednisone and plasmapheresis. To the best of our knowledge, this is the first reported case of thrombotic thrombocytopenic purpura associated with the use of moxifloxacin. Although rare, physicians should be aware of this serious complication associated with its use. |
| format | Article |
| id | doaj-art-b68de6cb07fb4ce586dcde8b7d97fb01 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b68de6cb07fb4ce586dcde8b7d97fb012025-08-20T02:23:08ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/459140459140Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic PurpuraSikander P. Surana0Zahily Sardinas1Alan S. Multz2Department of Medicine, Nassau University Medical Center, East Meadow, NY 11554, USADepartment of Medicine, Nassau University Medical Center, East Meadow, NY 11554, USADepartment of Medicine, Nassau University Medical Center, East Meadow, NY 11554, USAWe report a case of a 66-year-old African-American female who presented with complaints of progressively worsening weakness, shortness of breath on minimal exertion, lethargy for the last few days, and short episodes of aphasia lasting 20–30 seconds. Prior to presentation, she was treated with two courses of moxifloxacin for sinusitis. Laboratory examination was remarkable for anemia and thrombocytopenia with elevated lactate dehydrogenase and no evidence of renal failure. Peripheral smear showed numerous schistocytes and she was diagnosed with thrombotic thrombocytopenic purpura. Moxifloxacin was identified as the offending agent. The patient was treated with prednisone and plasmapheresis. To the best of our knowledge, this is the first reported case of thrombotic thrombocytopenic purpura associated with the use of moxifloxacin. Although rare, physicians should be aware of this serious complication associated with its use.http://dx.doi.org/10.1155/2012/459140 |
| spellingShingle | Sikander P. Surana Zahily Sardinas Alan S. Multz Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura Case Reports in Medicine |
| title | Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura |
| title_full | Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura |
| title_fullStr | Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura |
| title_full_unstemmed | Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura |
| title_short | Moxifloxacin (Avelox) Induced Thrombotic Thrombocytopenic Purpura |
| title_sort | moxifloxacin avelox induced thrombotic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2012/459140 |
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