Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss
Deafness is a common human disease, which is mainly caused by irreversible damage to hair cells and spiral ganglion neurons (SGNs) in the mammalian cochlea. At present, replacement of damaged or missing hair cells and SGNs by stem cell transplantation therapy is an effective treatment. However, the...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/9506387 |
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| _version_ | 1832551625906978816 |
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| author | Mingliang Tang Xiaoqian Yan Qilin Tang Rongrong Guo Peng Da Dan Li |
| author_facet | Mingliang Tang Xiaoqian Yan Qilin Tang Rongrong Guo Peng Da Dan Li |
| author_sort | Mingliang Tang |
| collection | DOAJ |
| description | Deafness is a common human disease, which is mainly caused by irreversible damage to hair cells and spiral ganglion neurons (SGNs) in the mammalian cochlea. At present, replacement of damaged or missing hair cells and SGNs by stem cell transplantation therapy is an effective treatment. However, the survival rate of stem cell transplantation is low, with uncontrollable differentiation hindering its application. Most researchers have focused on biochemical factors to regulate the growth and differentiation of stem cells, whereas little study has been performed using physical factors. This review intends to illustrate the current problems in stem cell-based treatment against deafness and to introduce electric field stimulation as a physical factor to regulate stem cell behavior and facilitate stem cell therapy to treat hearing loss in the future. |
| format | Article |
| id | doaj-art-b68d1b9b17de4993a2699ce0537e333c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b68d1b9b17de4993a2699ce0537e333c2025-02-03T06:00:59ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/95063879506387Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing LossMingliang Tang0Xiaoqian Yan1Qilin Tang2Rongrong Guo3Peng Da4Dan Li5Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, ChinaKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, ChinaThe First Clinical Medical School, Anhui Medical University, 81 Meishan Road, Hefei 230032, ChinaKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong 226001, ChinaKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, ChinaDeafness is a common human disease, which is mainly caused by irreversible damage to hair cells and spiral ganglion neurons (SGNs) in the mammalian cochlea. At present, replacement of damaged or missing hair cells and SGNs by stem cell transplantation therapy is an effective treatment. However, the survival rate of stem cell transplantation is low, with uncontrollable differentiation hindering its application. Most researchers have focused on biochemical factors to regulate the growth and differentiation of stem cells, whereas little study has been performed using physical factors. This review intends to illustrate the current problems in stem cell-based treatment against deafness and to introduce electric field stimulation as a physical factor to regulate stem cell behavior and facilitate stem cell therapy to treat hearing loss in the future.http://dx.doi.org/10.1155/2018/9506387 |
| spellingShingle | Mingliang Tang Xiaoqian Yan Qilin Tang Rongrong Guo Peng Da Dan Li Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss Neural Plasticity |
| title | Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss |
| title_full | Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss |
| title_fullStr | Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss |
| title_full_unstemmed | Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss |
| title_short | Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss |
| title_sort | potential application of electrical stimulation in stem cell based treatment against hearing loss |
| url | http://dx.doi.org/10.1155/2018/9506387 |
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