Body temperature regulates glucose metabolism and torpid behavior
Abstract Glucose is a significant energy resource for maintaining physiological activities, including body temperature homeostasis, and glucose homeostasis is tightly regulated in mammals. Although ambient temperature tunes glucose metabolism to maintain euthermia, the significance of body temperatu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61499-2 |
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| author | Ming-Liang Lee Ching-Pu Chang Chitoku Toda Tomomi Nemoto Ryosuke Enoki |
| author_facet | Ming-Liang Lee Ching-Pu Chang Chitoku Toda Tomomi Nemoto Ryosuke Enoki |
| author_sort | Ming-Liang Lee |
| collection | DOAJ |
| description | Abstract Glucose is a significant energy resource for maintaining physiological activities, including body temperature homeostasis, and glucose homeostasis is tightly regulated in mammals. Although ambient temperature tunes glucose metabolism to maintain euthermia, the significance of body temperature in metabolic regulation remains unclear owing to strict thermoregulation. Activation of Qrfp neurons in the preoptic area induced a harmless hypothermic state known as Q-neuron–induced hypothermia and hypometabolism (QIH), which is suitable for studying glucose metabolism under hypothermia. In this study, we observed that QIH mice had hyperinsulinemia and insulin resistance. This glucose hypometabolic state was abolished by increasing the body temperature to euthermia. Moreover, QIH-mediated inappetence and locomotor inactivity were recovered in euthermia QIH mice. These results indicate that body temperature is considerably more powerful than ambient temperature in regulating glucose metabolism and behavior, and the glucose hypometabolism in QIH is secondary to hypothermia rather than modulated by Qrfp neurons. |
| format | Article |
| id | doaj-art-b68bf2c9d313457f9f8d1002d12c48b5 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b68bf2c9d313457f9f8d1002d12c48b52025-08-20T03:05:10ZengNature PortfolioNature Communications2041-17232025-07-0116111510.1038/s41467-025-61499-2Body temperature regulates glucose metabolism and torpid behaviorMing-Liang Lee0Ching-Pu Chang1Chitoku Toda2Tomomi Nemoto3Ryosuke Enoki4Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS)Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS)Department of Neuroscience for Metabolic Control, Faculty of Life Sciences, Kumamoto UniversityExploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS)Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS)Abstract Glucose is a significant energy resource for maintaining physiological activities, including body temperature homeostasis, and glucose homeostasis is tightly regulated in mammals. Although ambient temperature tunes glucose metabolism to maintain euthermia, the significance of body temperature in metabolic regulation remains unclear owing to strict thermoregulation. Activation of Qrfp neurons in the preoptic area induced a harmless hypothermic state known as Q-neuron–induced hypothermia and hypometabolism (QIH), which is suitable for studying glucose metabolism under hypothermia. In this study, we observed that QIH mice had hyperinsulinemia and insulin resistance. This glucose hypometabolic state was abolished by increasing the body temperature to euthermia. Moreover, QIH-mediated inappetence and locomotor inactivity were recovered in euthermia QIH mice. These results indicate that body temperature is considerably more powerful than ambient temperature in regulating glucose metabolism and behavior, and the glucose hypometabolism in QIH is secondary to hypothermia rather than modulated by Qrfp neurons.https://doi.org/10.1038/s41467-025-61499-2 |
| spellingShingle | Ming-Liang Lee Ching-Pu Chang Chitoku Toda Tomomi Nemoto Ryosuke Enoki Body temperature regulates glucose metabolism and torpid behavior Nature Communications |
| title | Body temperature regulates glucose metabolism and torpid behavior |
| title_full | Body temperature regulates glucose metabolism and torpid behavior |
| title_fullStr | Body temperature regulates glucose metabolism and torpid behavior |
| title_full_unstemmed | Body temperature regulates glucose metabolism and torpid behavior |
| title_short | Body temperature regulates glucose metabolism and torpid behavior |
| title_sort | body temperature regulates glucose metabolism and torpid behavior |
| url | https://doi.org/10.1038/s41467-025-61499-2 |
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