KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis.

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis.

Kaposi's sarcoma (KS) herpesvirus (KSHV) causes KS, an angiogenic AIDS-associated spindle-cell neoplasm, by activating host oncogenic signaling cascades through autocrine and paracrine mechanisms. Tyrosine kinase receptor (RTK) proteomic arrays, identified PDGF receptor-alpha (PDGFRA) as the pr...

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Bibliographic Details
Main Authors: Lucas E Cavallin, Qi Ma, Julian Naipauer, Sachin Gupta, Mani Kurian, Paola Locatelli, Paolo Romanelli, Mehrdad Nadji, Pascal J Goldschmidt-Clermont, Enrique A Mesri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007175&type=printable
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