Phases I–III Clinical Trials Using Adult Stem Cells
First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2010/579142 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556633419415552 |
|---|---|
| author | Ricardo Sanz-Ruiz Enrique Gutiérrez Ibañes Adolfo Villa Arranz María Eugenia Fernández Santos Pedro L. Sánchez Fernández Francisco Fernández-Avilés |
| author_facet | Ricardo Sanz-Ruiz Enrique Gutiérrez Ibañes Adolfo Villa Arranz María Eugenia Fernández Santos Pedro L. Sánchez Fernández Francisco Fernández-Avilés |
| author_sort | Ricardo Sanz-Ruiz |
| collection | DOAJ |
| description | First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case of mechanisms of action and possible ways to improve clinical impact of stem cells in cardiac repair. In this paper we will examine the evidence available, analyze the main phase I and II randomized clinical trials and their limitations, discuss the key points in the design of future trials, and depict new directions of research in this fascinating field. |
| format | Article |
| id | doaj-art-b68311f6eabb4fc895c1540adc75360c |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b68311f6eabb4fc895c1540adc75360c2025-02-03T05:44:56ZengWileyStem Cells International1687-96782010-01-01201010.4061/2010/579142579142Phases I–III Clinical Trials Using Adult Stem CellsRicardo Sanz-Ruiz0Enrique Gutiérrez Ibañes1Adolfo Villa Arranz2María Eugenia Fernández Santos3Pedro L. Sánchez Fernández4Francisco Fernández-Avilés5Cardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainCardiology Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainFirst randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case of mechanisms of action and possible ways to improve clinical impact of stem cells in cardiac repair. In this paper we will examine the evidence available, analyze the main phase I and II randomized clinical trials and their limitations, discuss the key points in the design of future trials, and depict new directions of research in this fascinating field.http://dx.doi.org/10.4061/2010/579142 |
| spellingShingle | Ricardo Sanz-Ruiz Enrique Gutiérrez Ibañes Adolfo Villa Arranz María Eugenia Fernández Santos Pedro L. Sánchez Fernández Francisco Fernández-Avilés Phases I–III Clinical Trials Using Adult Stem Cells Stem Cells International |
| title | Phases I–III Clinical Trials Using Adult Stem Cells |
| title_full | Phases I–III Clinical Trials Using Adult Stem Cells |
| title_fullStr | Phases I–III Clinical Trials Using Adult Stem Cells |
| title_full_unstemmed | Phases I–III Clinical Trials Using Adult Stem Cells |
| title_short | Phases I–III Clinical Trials Using Adult Stem Cells |
| title_sort | phases i iii clinical trials using adult stem cells |
| url | http://dx.doi.org/10.4061/2010/579142 |
| work_keys_str_mv | AT ricardosanzruiz phasesiiiiclinicaltrialsusingadultstemcells AT enriquegutierrezibanes phasesiiiiclinicaltrialsusingadultstemcells AT adolfovillaarranz phasesiiiiclinicaltrialsusingadultstemcells AT mariaeugeniafernandezsantos phasesiiiiclinicaltrialsusingadultstemcells AT pedrolsanchezfernandez phasesiiiiclinicaltrialsusingadultstemcells AT franciscofernandezaviles phasesiiiiclinicaltrialsusingadultstemcells |