The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies
Antiphospholipid syndrome (APS) is an autoimmune disease mainly characterised by vascular thrombosis and pregnancy morbidity. APS has broad spectrum of clinical manifestations. The digestive system involvement of antiphospholipid syndrome is a critical but under-recognised condition. Digestive syste...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1962964 |
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| author | Jin Zhang Cheng Li Xiaorong Han Zhongbo Chen Binay Kumar Adhikari Yinghui Wang Yonggang Wang Jian Sun |
| author_facet | Jin Zhang Cheng Li Xiaorong Han Zhongbo Chen Binay Kumar Adhikari Yinghui Wang Yonggang Wang Jian Sun |
| author_sort | Jin Zhang |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APS) is an autoimmune disease mainly characterised by vascular thrombosis and pregnancy morbidity. APS has broad spectrum of clinical manifestations. The digestive system involvement of antiphospholipid syndrome is a critical but under-recognised condition. Digestive system involvement may be the result of direct (autoimmune-mediated) or indirect (thrombotic) mechanisms. Liver is the most commonly involved organ, followed by intestines, oesophagus, stomach, pancreas and spleen. This review describes possible digestive system manifestations in APS patients, and illustrates the epidemiology and possible pathophysiology of APS. The role of different treatment strategies in the management of digestive system manifestations of APS were also discussed.Key messagesAntiphospholipid syndrome is a multi-organ, multi-system disease and its clinical manifestation spectrum is gradually expanding. Since the first diagnosis of APS, the clinical manifestations of digestive system have been reported successively. This narrative review describes the major digestive system manifestations of APS and illustrates the epidemiology, pathophysiology and the role of therapeutic strategies of these patients. |
| format | Article |
| id | doaj-art-b68218ae8b0a4070b797f88e8dab3c99 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-b68218ae8b0a4070b797f88e8dab3c992025-08-20T03:43:57ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015311328133910.1080/07853890.2021.1962964The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategiesJin Zhang0Cheng Li1Xiaorong Han2Zhongbo Chen3Binay Kumar Adhikari4Yinghui Wang5Yonggang Wang6Jian Sun7Department of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Medicine, Nepal Armed Police Force Command and Staff hospital, Kathmandu, NepalDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaDepartment of Cardiovascular Center, Jilin University First Hospital, Changchun, ChinaAntiphospholipid syndrome (APS) is an autoimmune disease mainly characterised by vascular thrombosis and pregnancy morbidity. APS has broad spectrum of clinical manifestations. The digestive system involvement of antiphospholipid syndrome is a critical but under-recognised condition. Digestive system involvement may be the result of direct (autoimmune-mediated) or indirect (thrombotic) mechanisms. Liver is the most commonly involved organ, followed by intestines, oesophagus, stomach, pancreas and spleen. This review describes possible digestive system manifestations in APS patients, and illustrates the epidemiology and possible pathophysiology of APS. The role of different treatment strategies in the management of digestive system manifestations of APS were also discussed.Key messagesAntiphospholipid syndrome is a multi-organ, multi-system disease and its clinical manifestation spectrum is gradually expanding. Since the first diagnosis of APS, the clinical manifestations of digestive system have been reported successively. This narrative review describes the major digestive system manifestations of APS and illustrates the epidemiology, pathophysiology and the role of therapeutic strategies of these patients.https://www.tandfonline.com/doi/10.1080/07853890.2021.1962964Antiphospholipid syndromeantiphospholipid antibodiesautoimmunethrombosisdigestive system |
| spellingShingle | Jin Zhang Cheng Li Xiaorong Han Zhongbo Chen Binay Kumar Adhikari Yinghui Wang Yonggang Wang Jian Sun The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies Annals of Medicine Antiphospholipid syndrome antiphospholipid antibodies autoimmune thrombosis digestive system |
| title | The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies |
| title_full | The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies |
| title_fullStr | The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies |
| title_full_unstemmed | The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies |
| title_short | The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies |
| title_sort | digestive system involvement of antiphospholipid syndrome pathophysiology clinical characteristics and treatment strategies |
| topic | Antiphospholipid syndrome antiphospholipid antibodies autoimmune thrombosis digestive system |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1962964 |
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