Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications
Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications. Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less unde...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/273086 |
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| _version_ | 1849691845039226880 |
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| author | Xiaotian Zhong Jill F. Wright |
| author_facet | Xiaotian Zhong Jill F. Wright |
| author_sort | Xiaotian Zhong |
| collection | DOAJ |
| description | Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications. Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many. This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events. It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties. In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products. |
| format | Article |
| id | doaj-art-b67f201d8ebc489ca84403ef0d1d20b7 |
| institution | DOAJ |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-b67f201d8ebc489ca84403ef0d1d20b72025-08-20T03:20:54ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/273086273086Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical ApplicationsXiaotian Zhong0Jill F. Wright1Pfizer BioTherapeutics Research & Development, 87 Cambridge Park Drive, Cambridge, MA 02140, USAPfizer BioTherapeutics Research & Development, 87 Cambridge Park Drive, Cambridge, MA 02140, USAOver the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications. Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many. This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events. It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties. In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products.http://dx.doi.org/10.1155/2013/273086 |
| spellingShingle | Xiaotian Zhong Jill F. Wright Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications International Journal of Cell Biology |
| title | Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications |
| title_full | Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications |
| title_fullStr | Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications |
| title_full_unstemmed | Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications |
| title_short | Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications |
| title_sort | biological insights into therapeutic protein modifications throughout trafficking and their biopharmaceutical applications |
| url | http://dx.doi.org/10.1155/2013/273086 |
| work_keys_str_mv | AT xiaotianzhong biologicalinsightsintotherapeuticproteinmodificationsthroughouttraffickingandtheirbiopharmaceuticalapplications AT jillfwright biologicalinsightsintotherapeuticproteinmodificationsthroughouttraffickingandtheirbiopharmaceuticalapplications |