Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Abstract Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two independent pathways, controlled by the polymerase REV1 and ubiquitinated PCNA, respectively. Results To determine the molecular and ge...

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Bibliographic Details
Main Authors: Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-024-03451-z
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