Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice

Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice

Abstract Depression and comorbid pain are frequently encountered clinically, and the comorbidity complicates the overall medical management. However, the mechanism whereby depression triggers development of pain needs to be further elucidated. Here, by using the chronic restraint stress (CRS) mouse...

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Main Authors: Xianlei Wang, Shulin Wu, Junsheng Zuo, Keying Li, Yutong Chen, Zhijie Fan, Zhou Wu, Jun-Xia Yang, Weiyi Song, Jun-Li Cao, Mengqiao Cui
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07590-2
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