Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia
Tranexamic acid (TXA) allergy is extremely rare. An 80-year-old woman without prior exposure to TXA underwent elective knee replacement. Shortly after induction of anaesthesia and intravenous TXA, she developed hypotension, tachycardia, and facial erythema accompanied by a raised serum tryptase. Lat...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2016/7828351 |
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| author | R. A. Bansal A. Nicholas A. S. Bansal |
| author_facet | R. A. Bansal A. Nicholas A. S. Bansal |
| author_sort | R. A. Bansal |
| collection | DOAJ |
| description | Tranexamic acid (TXA) allergy is extremely rare. An 80-year-old woman without prior exposure to TXA underwent elective knee replacement. Shortly after induction of anaesthesia and intravenous TXA, she developed hypotension, tachycardia, and facial erythema accompanied by a raised serum tryptase. Later, skin prick and intradermal testing confirmed positive responses to TXA in high dilution and with negative results to the other drugs used. While neuromuscular blocking agents, opiates, and antibiotics remain the most frequent cause of anaphylaxis during anaesthesia, allergy to TXA should always be borne in mind and requires skin testing for confirmation as there are presently no blood tests available. |
| format | Article |
| id | doaj-art-b663ec4b09864d6ea736d49e12a47f0e |
| institution | DOAJ |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-b663ec4b09864d6ea736d49e12a47f0e2025-08-20T03:20:54ZengWileyCase Reports in Immunology2090-66092090-66172016-01-01201610.1155/2016/78283517828351Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during AnaesthesiaR. A. Bansal0A. Nicholas1A. S. Bansal2Department of Immunology and Allergy, St Helier Hospital, Carshalton, Surrey SM5 1AA, UKDepartment of Immunology and Allergy, St Helier Hospital, Carshalton, Surrey SM5 1AA, UKDepartment of Immunology and Allergy, St Helier Hospital, Carshalton, Surrey SM5 1AA, UKTranexamic acid (TXA) allergy is extremely rare. An 80-year-old woman without prior exposure to TXA underwent elective knee replacement. Shortly after induction of anaesthesia and intravenous TXA, she developed hypotension, tachycardia, and facial erythema accompanied by a raised serum tryptase. Later, skin prick and intradermal testing confirmed positive responses to TXA in high dilution and with negative results to the other drugs used. While neuromuscular blocking agents, opiates, and antibiotics remain the most frequent cause of anaphylaxis during anaesthesia, allergy to TXA should always be borne in mind and requires skin testing for confirmation as there are presently no blood tests available.http://dx.doi.org/10.1155/2016/7828351 |
| spellingShingle | R. A. Bansal A. Nicholas A. S. Bansal Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia Case Reports in Immunology |
| title | Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia |
| title_full | Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia |
| title_fullStr | Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia |
| title_full_unstemmed | Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia |
| title_short | Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia |
| title_sort | tranexamic acid an exceedingly rare cause of anaphylaxis during anaesthesia |
| url | http://dx.doi.org/10.1155/2016/7828351 |
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