Acute transaminitis after initial days of starting haloperidol
Haloperidol is a first-generation antipsychotic butyrophenone that is lipophilic, readily absorbed, and extensively metabolized in the liver. The occurrence of elevated liver enzymes with haloperidol is reported to be 2.4% with cases generally occurring in the setting of chronic use. In this case, w...
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Mental Illness |
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| Online Access: | https://www.pagepress.org/journals/index.php/mi/article/view/8113 |
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| author | Rami Gabriel Todd Wojtanowicz Reza Farokhpay Robert Bota |
| author_facet | Rami Gabriel Todd Wojtanowicz Reza Farokhpay Robert Bota |
| author_sort | Rami Gabriel |
| collection | DOAJ |
| description | Haloperidol is a first-generation antipsychotic butyrophenone that is lipophilic, readily absorbed, and extensively metabolized in the liver. The occurrence of elevated liver enzymes with haloperidol is reported to be 2.4% with cases generally occurring in the setting of chronic use. In this case, we present a patient who developed elevated liver enzymes 1-2 days after starting haloperidol treatment on two separate occasions and in the context of negative hepatic viral and autoimmune serology. Liver enzymes consistently had alanine transaminase > aspartate transaminase and peaked at 288 U/L prior to discontinuation of the medication. The patient was taken off haloperidol after serology resulted and clozapine regimen started. He was able to tolerate clozapine well with recovery of his transaminitis and psychiatric stabilization. |
| format | Article |
| id | doaj-art-b6579c851c1a4dc0acf76fb4edb88e81 |
| institution | DOAJ |
| issn | 2036-7457 2036-7465 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mental Illness |
| spelling | doaj-art-b6579c851c1a4dc0acf76fb4edb88e812025-08-20T03:20:54ZengWileyMental Illness2036-74572036-74652019-06-0111110.4081/mi.2019.8113Acute transaminitis after initial days of starting haloperidolRami Gabriel0Todd Wojtanowicz1Reza Farokhpay2Robert Bota3School of Medicine, University of California, Irvine, CADepartment of Psychiatry, University of California, Irvine, CASchool of Medicine, and Department of Psychiatry, University of California, Irvine, CASchool of Medicine, and Department of Psychiatry, University of California, Irvine, CAHaloperidol is a first-generation antipsychotic butyrophenone that is lipophilic, readily absorbed, and extensively metabolized in the liver. The occurrence of elevated liver enzymes with haloperidol is reported to be 2.4% with cases generally occurring in the setting of chronic use. In this case, we present a patient who developed elevated liver enzymes 1-2 days after starting haloperidol treatment on two separate occasions and in the context of negative hepatic viral and autoimmune serology. Liver enzymes consistently had alanine transaminase > aspartate transaminase and peaked at 288 U/L prior to discontinuation of the medication. The patient was taken off haloperidol after serology resulted and clozapine regimen started. He was able to tolerate clozapine well with recovery of his transaminitis and psychiatric stabilization.https://www.pagepress.org/journals/index.php/mi/article/view/8113HaldolTransaminitisSchizophreniaLiver toxicity |
| spellingShingle | Rami Gabriel Todd Wojtanowicz Reza Farokhpay Robert Bota Acute transaminitis after initial days of starting haloperidol Mental Illness Haldol Transaminitis Schizophrenia Liver toxicity |
| title | Acute transaminitis after initial days of starting haloperidol |
| title_full | Acute transaminitis after initial days of starting haloperidol |
| title_fullStr | Acute transaminitis after initial days of starting haloperidol |
| title_full_unstemmed | Acute transaminitis after initial days of starting haloperidol |
| title_short | Acute transaminitis after initial days of starting haloperidol |
| title_sort | acute transaminitis after initial days of starting haloperidol |
| topic | Haldol Transaminitis Schizophrenia Liver toxicity |
| url | https://www.pagepress.org/journals/index.php/mi/article/view/8113 |
| work_keys_str_mv | AT ramigabriel acutetransaminitisafterinitialdaysofstartinghaloperidol AT toddwojtanowicz acutetransaminitisafterinitialdaysofstartinghaloperidol AT rezafarokhpay acutetransaminitisafterinitialdaysofstartinghaloperidol AT robertbota acutetransaminitisafterinitialdaysofstartinghaloperidol |