A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique
An efficient method for the synthesis of 3-arylidenechroman-4-ones has been developed under solvent free conditions using grinding technique. Grinding of variously substituted chroman-4-ones with aromatic aldehydes in presence of anhydrous barium hydroxide at room temperature give 3-arylidenechroman...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/324907 |
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| author | Suresh Kumar Jagdish K. Makrandi |
| author_facet | Suresh Kumar Jagdish K. Makrandi |
| author_sort | Suresh Kumar |
| collection | DOAJ |
| description | An efficient method for the synthesis of 3-arylidenechroman-4-ones has been developed under solvent free conditions using grinding technique. Grinding of variously substituted chroman-4-ones with aromatic aldehydes in presence of anhydrous barium hydroxide at room temperature give 3-arylidenechroman-4-ones in high yield (75-92%). Products are obtained by just acidification of the reaction mixture in ice cold water. Reaction in solid state, with enhanced rate, high selectivity and manipulative simplicity are the attractive features of this environmentally benign protocol. The chroman-4-one derivatives required for the reaction have been obtained by polyphosphoric acid (PPA) catalysed cyclisation of phenoxypropanoic acids under microwave irradiations. |
| format | Article |
| id | doaj-art-b6556cdfc4cc46498499afc4a54563e1 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-b6556cdfc4cc46498499afc4a54563e12025-08-20T02:23:11ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931251125610.1155/2012/324907A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding TechniqueSuresh Kumar0Jagdish K. Makrandi1Department of Chemistry, Kurukshetra University, Kurukshetra, IndiaDepartment of Chemistry, M.D. University Rohtak, IndiaAn efficient method for the synthesis of 3-arylidenechroman-4-ones has been developed under solvent free conditions using grinding technique. Grinding of variously substituted chroman-4-ones with aromatic aldehydes in presence of anhydrous barium hydroxide at room temperature give 3-arylidenechroman-4-ones in high yield (75-92%). Products are obtained by just acidification of the reaction mixture in ice cold water. Reaction in solid state, with enhanced rate, high selectivity and manipulative simplicity are the attractive features of this environmentally benign protocol. The chroman-4-one derivatives required for the reaction have been obtained by polyphosphoric acid (PPA) catalysed cyclisation of phenoxypropanoic acids under microwave irradiations.http://dx.doi.org/10.1155/2012/324907 |
| spellingShingle | Suresh Kumar Jagdish K. Makrandi A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique E-Journal of Chemistry |
| title | A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique |
| title_full | A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique |
| title_fullStr | A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique |
| title_full_unstemmed | A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique |
| title_short | A Facile Solvent Free Synthesis of 3-arylidenechroman-4-ones Using Grinding Technique |
| title_sort | facile solvent free synthesis of 3 arylidenechroman 4 ones using grinding technique |
| url | http://dx.doi.org/10.1155/2012/324907 |
| work_keys_str_mv | AT sureshkumar afacilesolventfreesynthesisof3arylidenechroman4onesusinggrindingtechnique AT jagdishkmakrandi afacilesolventfreesynthesisof3arylidenechroman4onesusinggrindingtechnique AT sureshkumar facilesolventfreesynthesisof3arylidenechroman4onesusinggrindingtechnique AT jagdishkmakrandi facilesolventfreesynthesisof3arylidenechroman4onesusinggrindingtechnique |