Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort

Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort

Abstract Detecting homozygous deletion (HD) of CDKN2A is critical in BRAF-altered gliomas, as this molecular alteration has both diagnostic and prognostic significance. It is predominantly associated with BRAF-altered high-grade gliomas and has been associated with poorer prognosis in certain BRAF-a...

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Bibliographic Details
Main Authors:	Thibaut Wolf, Damien Reita, Marlène Deschuyter, Chinar Salmanli, Julie Buffa, Erwan Pencreach, Eric Guérin, Eric Jeandidier, Marguerite Miguet, Marie-Pierre Chenard, Lucas Geyer, Georges Noel, Julien Todeschi, Guillaume Gauchotte, Sophie Martin, Natacha Entz-Werlé, Benoît Lhermitte
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	Acta Neuropathologica Communications
Subjects:	p16 CDKN2A homozygous deletion FISH DNA methylation BRAF-altered gliomas
Online Access:	https://doi.org/10.1186/s40478-025-02089-7
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