Mechanisms Linking Inflammation to Insulin Resistance
Obesity is now widespread around the world. Obesity-associated chronic low-grade inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a major risk factor for insulin resistance and related diseases such as type 2 diabetes mellitus and metabolic syndromes. The stat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/508409 |
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| _version_ | 1849691765341159424 |
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| author | Li Chen Rui Chen Hua Wang Fengxia Liang |
| author_facet | Li Chen Rui Chen Hua Wang Fengxia Liang |
| author_sort | Li Chen |
| collection | DOAJ |
| description | Obesity is now widespread around the world. Obesity-associated chronic low-grade inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a major risk factor for insulin resistance and related diseases such as type 2 diabetes mellitus and metabolic syndromes. The state of low-grade inflammation is caused by overnutrition which leads to lipid accumulation in adipocytes. Obesity might increase the expression of some inflammatory cytokines and activate several signaling pathways, both of which are involved in the pathogenesis of insulin resistance by interfering with insulin signaling and action. It has been suggested that specific factors and signaling pathways are often correlated with each other; therefore, both of the fluctuation of cytokines and the status of relevant signaling pathways should be considered during studies analyzing inflammation-related insulin resistance. In this paper, we discuss how these factors and signaling pathways contribute to insulin resistance and the therapeutic promise targeting inflammation in insulin resistance based on the latest experimental studies. |
| format | Article |
| id | doaj-art-b649534f3da443a7ae2c07c1f4ea820e |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b649534f3da443a7ae2c07c1f4ea820e2025-08-20T03:20:55ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/508409508409Mechanisms Linking Inflammation to Insulin ResistanceLi Chen0Rui Chen1Hua Wang2Fengxia Liang3Hubei University of Chinese Medicine, Wuhan 430061, ChinaIntegrated TCM and Western Medicine Department, Union Hospital, Tongji Medical College of Huazhong Science and Technology University, Wuhan 430022, ChinaHubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Wuhan 430061, ChinaHubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Wuhan 430061, ChinaObesity is now widespread around the world. Obesity-associated chronic low-grade inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a major risk factor for insulin resistance and related diseases such as type 2 diabetes mellitus and metabolic syndromes. The state of low-grade inflammation is caused by overnutrition which leads to lipid accumulation in adipocytes. Obesity might increase the expression of some inflammatory cytokines and activate several signaling pathways, both of which are involved in the pathogenesis of insulin resistance by interfering with insulin signaling and action. It has been suggested that specific factors and signaling pathways are often correlated with each other; therefore, both of the fluctuation of cytokines and the status of relevant signaling pathways should be considered during studies analyzing inflammation-related insulin resistance. In this paper, we discuss how these factors and signaling pathways contribute to insulin resistance and the therapeutic promise targeting inflammation in insulin resistance based on the latest experimental studies.http://dx.doi.org/10.1155/2015/508409 |
| spellingShingle | Li Chen Rui Chen Hua Wang Fengxia Liang Mechanisms Linking Inflammation to Insulin Resistance International Journal of Endocrinology |
| title | Mechanisms Linking Inflammation to Insulin Resistance |
| title_full | Mechanisms Linking Inflammation to Insulin Resistance |
| title_fullStr | Mechanisms Linking Inflammation to Insulin Resistance |
| title_full_unstemmed | Mechanisms Linking Inflammation to Insulin Resistance |
| title_short | Mechanisms Linking Inflammation to Insulin Resistance |
| title_sort | mechanisms linking inflammation to insulin resistance |
| url | http://dx.doi.org/10.1155/2015/508409 |
| work_keys_str_mv | AT lichen mechanismslinkinginflammationtoinsulinresistance AT ruichen mechanismslinkinginflammationtoinsulinresistance AT huawang mechanismslinkinginflammationtoinsulinresistance AT fengxialiang mechanismslinkinginflammationtoinsulinresistance |