The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization
<br> Kuroyedov A.V.<sup>1,2</sup>, Zakharova M.A.<sup>3</sup>, Gaponko O.V.<sup>1</sup>, Gorodnichy V.V.<sup>1</sup><br> <br> <sup>1</sup> Central Military Clinical Hospital named after P. V. Mandryka, Moscow<br>...
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| Format: | Article |
| Language: | Russian |
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Prime-Media
2018-07-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/7b4/7b467e72ed1c1d901eaef66a83a5e862.pdf |
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| author | A.V. Kuroyedov Zakharova M.A. O.V. Gapon’ko V.V. Gorodnichiy |
| author_facet | A.V. Kuroyedov Zakharova M.A. O.V. Gapon’ko V.V. Gorodnichiy |
| author_sort | A.V. Kuroyedov |
| collection | DOAJ |
| description | <br>
Kuroyedov A.V.<sup>1,2</sup>, Zakharova M.A.<sup>3</sup>, Gaponko O.V.<sup>1</sup>, Gorodnichy V.V.<sup>1</sup><br>
<br>
<sup>1</sup> Central Military Clinical Hospital named after P. V. Mandryka, Moscow<br>
<sup>2</sup> Pirogov Russian National Research Medical University, Moscow<br>
<sup>3</sup> S. Fyodorov Eye Microsurgery Federal State Institution, Moscow<br>
<br>
<b>Aim</b>: to study the changes in the level of intraocular pressure (IOP) in the early period after the intravitreal administration of anti-VEGF drugs in patients with classical and occult choroidal neovascularization (CNV).<br>
<b>Patients and Methods:</b> 34 patients (40 eyes) with age-related macular degeneration were divided into 2 groups. Group 1 — the patients (19 eyes) with classic CNV, group 2 — the patients (21 eyes) with occult CNV. In all patients the IOP were measured an hour before the treatment, on the 7-th day after the injection of ranibizumab and at the 1-month follow-up visit.<br>
<b>Results</b>: in group 1 the level of IOP increased an hour after the injection, but on the 7th day it was already at the initial level, which persisted after 1 month (p>0,05). In the second group, the IOP level remained stable throughout the follow-up period <br>
(p <0.05). Differences in the level of IOP in an hour, on the 7th day and 1 month after intravitreal injection in patients of both groups and between groups were not detected (p> 0.05). There was no significant difference in retinal thickness before and after intravitreal injection in both groups (p> 0.05). However, significant difference was noted in patients of both groups in corrected visual acuity before and after treatment (p<0.05).<br>
<b>Conclusions</b>: in patients with a classical choroidal neovascularization, an increase in the IOP level was observed one hour after the intravitreal administration of anti-VEGF drugs. The difference in the IOP-level in patients with age-related macular degeneration in the group with classical CNV and in the group with occult CNV after intravitreal injection of the anti-VEGF was not detected in an hour, on the 7th day and 1 month after the administration of the anti-VEGF preparation.<br>
<br>
<b>Key words:</b> anti-VEGF drugs, IOP-level, choroidal neovascularization, age-related macular degeneration.<br>
<b>For citation:</b> Kuroyedov A.V., Zakharova M.A., Gaponko O.V., Gorodnichy V.V. The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization. <br>
RMJ “Clinical ophthalmology”. 2018;2:102–106.<br> |
| format | Article |
| id | doaj-art-b6463f9346d742059a9e3eba77f442da |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2018-07-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-b6463f9346d742059a9e3eba77f442da2025-01-16T09:39:39ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712018-07-0118210117The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularizationA.V. Kuroyedov0Zakharova M.A.1O.V. Gapon’ko2V.V. Gorodnichiy3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<br> Kuroyedov A.V.<sup>1,2</sup>, Zakharova M.A.<sup>3</sup>, Gaponko O.V.<sup>1</sup>, Gorodnichy V.V.<sup>1</sup><br> <br> <sup>1</sup> Central Military Clinical Hospital named after P. V. Mandryka, Moscow<br> <sup>2</sup> Pirogov Russian National Research Medical University, Moscow<br> <sup>3</sup> S. Fyodorov Eye Microsurgery Federal State Institution, Moscow<br> <br> <b>Aim</b>: to study the changes in the level of intraocular pressure (IOP) in the early period after the intravitreal administration of anti-VEGF drugs in patients with classical and occult choroidal neovascularization (CNV).<br> <b>Patients and Methods:</b> 34 patients (40 eyes) with age-related macular degeneration were divided into 2 groups. Group 1 — the patients (19 eyes) with classic CNV, group 2 — the patients (21 eyes) with occult CNV. In all patients the IOP were measured an hour before the treatment, on the 7-th day after the injection of ranibizumab and at the 1-month follow-up visit.<br> <b>Results</b>: in group 1 the level of IOP increased an hour after the injection, but on the 7th day it was already at the initial level, which persisted after 1 month (p>0,05). In the second group, the IOP level remained stable throughout the follow-up period <br> (p <0.05). Differences in the level of IOP in an hour, on the 7th day and 1 month after intravitreal injection in patients of both groups and between groups were not detected (p> 0.05). There was no significant difference in retinal thickness before and after intravitreal injection in both groups (p> 0.05). However, significant difference was noted in patients of both groups in corrected visual acuity before and after treatment (p<0.05).<br> <b>Conclusions</b>: in patients with a classical choroidal neovascularization, an increase in the IOP level was observed one hour after the intravitreal administration of anti-VEGF drugs. The difference in the IOP-level in patients with age-related macular degeneration in the group with classical CNV and in the group with occult CNV after intravitreal injection of the anti-VEGF was not detected in an hour, on the 7th day and 1 month after the administration of the anti-VEGF preparation.<br> <br> <b>Key words:</b> anti-VEGF drugs, IOP-level, choroidal neovascularization, age-related macular degeneration.<br> <b>For citation:</b> Kuroyedov A.V., Zakharova M.A., Gaponko O.V., Gorodnichy V.V. The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization. <br> RMJ “Clinical ophthalmology”. 2018;2:102–106.<br>http://clinopht.com/upload/iblock/7b4/7b467e72ed1c1d901eaef66a83a5e862.pdf |
| spellingShingle | A.V. Kuroyedov Zakharova M.A. O.V. Gapon’ko V.V. Gorodnichiy The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization РМЖ "Клиническая офтальмология" |
| title | The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| title_full | The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| title_fullStr | The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| title_full_unstemmed | The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| title_short | The effect of intravitreal injection of anti-VEGF drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| title_sort | effect of intravitreal injection of anti vegf drugs on the ophthalmotonus values in patients with classic and occult choroidal neovascularization |
| url | http://clinopht.com/upload/iblock/7b4/7b467e72ed1c1d901eaef66a83a5e862.pdf |
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