Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient
Huntington's disease (HD) is a genetic, degenerative, and progressive central nervous system disease. It is characterized by motor abnormalities and cognitive and psychiatric symptoms. Objective. To describe the precise degree of clinical severity of patients with HD through a new neurocognitiv...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/385894 |
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| author | Anna Lucia Spear King Alexandre Martins Valença Adriana Cardoso de Oliveira e Silva Ana Claudia Cerqueira Lígia Maria Chaves Ferraz Antonio Egidio Nardi |
| author_facet | Anna Lucia Spear King Alexandre Martins Valença Adriana Cardoso de Oliveira e Silva Ana Claudia Cerqueira Lígia Maria Chaves Ferraz Antonio Egidio Nardi |
| author_sort | Anna Lucia Spear King |
| collection | DOAJ |
| description | Huntington's disease (HD) is a genetic, degenerative, and progressive central nervous system disease. It is characterized by motor abnormalities and cognitive and psychiatric symptoms. Objective. To describe the precise degree of clinical severity of patients with HD through a new neurocognitive assessment. Methods. Unprecedented battery of computerized tests, CNSVS (Central Nervous System Vital Signs), was applied at three different moments in 2008, 2009, and 2010. The accurate and reliable CNSVS objectively provided the cognitive state of patients and allowed for the evaluation of disease progression. Case Report. P., 26, female, without any medication, with normal psychomotor development is a parent carrier of HD. In 2008, she was diagnosed with HD in accordance with the Medical Genetics Laboratories. Conclusion. The tests may be useful to reveal the exact measure of the current evolutionary stage of HD patients, allowing for more efficient planning of treatment and future procedures, such as the medication, therapy, and physical activity to be administered. |
| format | Article |
| id | doaj-art-b6440e5c1049462db2ec2d5da84fe838 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b6440e5c1049462db2ec2d5da84fe8382025-08-20T02:23:09ZengWileyCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/385894385894Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult PatientAnna Lucia Spear King0Alexandre Martins Valença1Adriana Cardoso de Oliveira e Silva2Ana Claudia Cerqueira3Lígia Maria Chaves Ferraz4Antonio Egidio Nardi5Laboratory of Panic and Respiration (LABPR), Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), RJ, BrazilLaboratory of Panic and Respiration (LABPR), Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), RJ, BrazilLaboratory of Panic and Respiration (LABPR), Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), RJ, BrazilLaboratory of Panic and Respiration (LABPR), Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), RJ, BrazilInstituto de Psiquiatria (IPUB), Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro (UFRJ), Av. Venceslau Brás, 71 Praia Vermelha, Cep 22290-140, Rio de Janeiro, RJ, BrazilLaboratory of Panic and Respiration (LABPR), Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), RJ, BrazilHuntington's disease (HD) is a genetic, degenerative, and progressive central nervous system disease. It is characterized by motor abnormalities and cognitive and psychiatric symptoms. Objective. To describe the precise degree of clinical severity of patients with HD through a new neurocognitive assessment. Methods. Unprecedented battery of computerized tests, CNSVS (Central Nervous System Vital Signs), was applied at three different moments in 2008, 2009, and 2010. The accurate and reliable CNSVS objectively provided the cognitive state of patients and allowed for the evaluation of disease progression. Case Report. P., 26, female, without any medication, with normal psychomotor development is a parent carrier of HD. In 2008, she was diagnosed with HD in accordance with the Medical Genetics Laboratories. Conclusion. The tests may be useful to reveal the exact measure of the current evolutionary stage of HD patients, allowing for more efficient planning of treatment and future procedures, such as the medication, therapy, and physical activity to be administered.http://dx.doi.org/10.1155/2011/385894 |
| spellingShingle | Anna Lucia Spear King Alexandre Martins Valença Adriana Cardoso de Oliveira e Silva Ana Claudia Cerqueira Lígia Maria Chaves Ferraz Antonio Egidio Nardi Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient Case Reports in Medicine |
| title | Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient |
| title_full | Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient |
| title_fullStr | Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient |
| title_full_unstemmed | Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient |
| title_short | Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient |
| title_sort | huntington s disease two year observational follow up of executive function evaluation with cns vital signs test in an adult patient |
| url | http://dx.doi.org/10.1155/2011/385894 |
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