Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells

Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells

Abstract Non-shivering thermogenesis of brown adipose tissue (BAT) is tightly controlled by neural innervation. However, the underlying mechanism remains unclear. Here, we reveal that BAT regulates its own thermoadaptive innervation by crosstalk with Schwann cells (SCs). Loss of Olfm4 (encoding Olfa...

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Main Authors: Mingqiang Lai, Wu Zhou, Wenchong Zou, Lianlian Qiu, Zhaoyu Liang, Wanyi Chen, Yiqing Wang, Bin Guo, Chaoran Zhao, Sheng Zhang, Pinglin Lai, Le Hu, Xiaolin Liu, Yu Jiang, Yinghua Chen, Min-jun Huang, Xiaochun Bai, Zhipeng Zou
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60474-1
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