MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN
Keratoconus is a progressive degenerative corneal disease. It causes a disruption in the structure and organization of the corneal collagen matrix and leads to its thinning and protrusion. In children keratoconus progresses faster and differs in more severe course, compared with adults. It is associ...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2017-10-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/388 |
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| author | E. Y. Markova S. V. Kostenev A. G. Grigor’eva E. A. Perfileva |
| author_facet | E. Y. Markova S. V. Kostenev A. G. Grigor’eva E. A. Perfileva |
| author_sort | E. Y. Markova |
| collection | DOAJ |
| description | Keratoconus is a progressive degenerative corneal disease. It causes a disruption in the structure and organization of the corneal collagen matrix and leads to its thinning and protrusion. In children keratoconus progresses faster and differs in more severe course, compared with adults. It is associated with the age structure of the child’s cornea. Until recently, the treatment of keratoconus included visual rehabilitation in the early stages and surgical treatment in advanced stages. Both methods didn’t have any effect on the disease’s pathogenesis. Cross-linking is a method inhibiting the progression of keratoconus, it allows to change the treatment approach fundamentally. Cross-linking is the only method directly acting on the pathogenesis of keratoconus, forming new molecular bonds between the collagen filaments, strengthening the corneal stroma and changing its biomechanical properties, which allows to slow the disease’s progression. Taking into account the peculiarities of keratoconus development in children, cross linking in children’s practice is even more perspective than in adults. Nevertheless, the novelty of the method, the lack of long-term studies about the effects for the child’s cornea and the variability of treatment protocols, are the main factors for the careful use this method in children. This work is a literature review describing the principles, advantages and limitations of the use of different types of cross-breeding in children with an analysis of the evidence base and consideration of possible options for the development of this method in children’s practice in the future. |
| format | Article |
| id | doaj-art-b63ed55d765b468986e2c452b8986491 |
| institution | DOAJ |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2017-10-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-b63ed55d765b468986e2c452b89864912025-08-20T02:56:15ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452017-10-0114318819410.18008/1816-5095-2017-3-188-194346MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDRENE. Y. Markova0S. V. Kostenev1A. G. Grigor’eva2E. A. Perfileva3The S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionThe S. Fyodorov Eye Microsurgery Federal State InstitutionKeratoconus is a progressive degenerative corneal disease. It causes a disruption in the structure and organization of the corneal collagen matrix and leads to its thinning and protrusion. In children keratoconus progresses faster and differs in more severe course, compared with adults. It is associated with the age structure of the child’s cornea. Until recently, the treatment of keratoconus included visual rehabilitation in the early stages and surgical treatment in advanced stages. Both methods didn’t have any effect on the disease’s pathogenesis. Cross-linking is a method inhibiting the progression of keratoconus, it allows to change the treatment approach fundamentally. Cross-linking is the only method directly acting on the pathogenesis of keratoconus, forming new molecular bonds between the collagen filaments, strengthening the corneal stroma and changing its biomechanical properties, which allows to slow the disease’s progression. Taking into account the peculiarities of keratoconus development in children, cross linking in children’s practice is even more perspective than in adults. Nevertheless, the novelty of the method, the lack of long-term studies about the effects for the child’s cornea and the variability of treatment protocols, are the main factors for the careful use this method in children. This work is a literature review describing the principles, advantages and limitations of the use of different types of cross-breeding in children with an analysis of the evidence base and consideration of possible options for the development of this method in children’s practice in the future.https://www.ophthalmojournal.com/opht/article/view/388keratoconuscorneacross-linkingсhild |
| spellingShingle | E. Y. Markova S. V. Kostenev A. G. Grigor’eva E. A. Perfileva MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN Oftalʹmologiâ keratoconus cornea cross-linking сhild |
| title | MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN |
| title_full | MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN |
| title_fullStr | MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN |
| title_full_unstemmed | MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN |
| title_short | MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN |
| title_sort | modern trends in the treatment of keratokonus in children |
| topic | keratoconus cornea cross-linking сhild |
| url | https://www.ophthalmojournal.com/opht/article/view/388 |
| work_keys_str_mv | AT eymarkova moderntrendsinthetreatmentofkeratokonusinchildren AT svkostenev moderntrendsinthetreatmentofkeratokonusinchildren AT aggrigoreva moderntrendsinthetreatmentofkeratokonusinchildren AT eaperfileva moderntrendsinthetreatmentofkeratokonusinchildren |