Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma
Background/Aim. Autophagy, a cellular degradation process, has paradoxical roles in tumorigenesis and the progression of human cancers. The aim of this study was to investigate the expression levels of autophagy-related proteins in colorectal cancer (CRC) and to evaluate their prognostic significanc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/179586 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159864757616640 |
|---|---|
| author | Ji Hye Choi Young-Seok Cho Yoon Ho Ko Soon Uk Hong Jin Hee Park Myung Ah Lee |
| author_facet | Ji Hye Choi Young-Seok Cho Yoon Ho Ko Soon Uk Hong Jin Hee Park Myung Ah Lee |
| author_sort | Ji Hye Choi |
| collection | DOAJ |
| description | Background/Aim. Autophagy, a cellular degradation process, has paradoxical roles in tumorigenesis and the progression of human cancers. The aim of this study was to investigate the expression levels of autophagy-related proteins in colorectal cancer (CRC) and to evaluate their prognostic significance. Methods. This study is a retrospective review of immunohistochemical and clinicopathological data. All specimens evaluated were obtained from 263 patients with colorectal cancer who had undergone surgery between November 1996 and August 2007. The primary outcomes measured were the expression levels of three autophagy-related proteins (ATG5, BECN1/Beclin 1, and Microtubule-associated protein 1 light chain 3B (LC3B)) by immunohistochemistry and its association in clinicopathological parameters and patient survival. Results. The autophagy-related protein expression frequencies were 65.1% (151/232) for ATG5, 71.3% (174/244) for BECN1, and 74.7% (186/249) for LC3B for the 263 patients. Correlation between the expression of autophagy-related proteins was significant for all protein pairs. Multivariate analysis showed that negative LC3B expression and absence of autophagy-related proteins expression were independently associated with poor prognosis. Conclusion. Absence of autophagy-related proteins expression is associated with poor clinical outcome in CRC, suggesting that these proteins have potential uses as novel prognostic markers. |
| format | Article |
| id | doaj-art-b63c13c1166e4d78a6fbcfa80ce8dd8e |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b63c13c1166e4d78a6fbcfa80ce8dd8e2025-08-20T02:23:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/179586179586Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal AdenocarcinomaJi Hye Choi0Young-Seok Cho1Yoon Ho Ko2Soon Uk Hong3Jin Hee Park4Myung Ah Lee5Department of Biomedical Science, The Catholic University of Korea College of Medicine, Seoul 137-701, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480-717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480-717, Republic of KoreaDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of KoreaDepartment of Biomedical Science, The Catholic University of Korea College of Medicine, Seoul 137-701, Republic of KoreaDepartment of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul 137-701, Republic of KoreaBackground/Aim. Autophagy, a cellular degradation process, has paradoxical roles in tumorigenesis and the progression of human cancers. The aim of this study was to investigate the expression levels of autophagy-related proteins in colorectal cancer (CRC) and to evaluate their prognostic significance. Methods. This study is a retrospective review of immunohistochemical and clinicopathological data. All specimens evaluated were obtained from 263 patients with colorectal cancer who had undergone surgery between November 1996 and August 2007. The primary outcomes measured were the expression levels of three autophagy-related proteins (ATG5, BECN1/Beclin 1, and Microtubule-associated protein 1 light chain 3B (LC3B)) by immunohistochemistry and its association in clinicopathological parameters and patient survival. Results. The autophagy-related protein expression frequencies were 65.1% (151/232) for ATG5, 71.3% (174/244) for BECN1, and 74.7% (186/249) for LC3B for the 263 patients. Correlation between the expression of autophagy-related proteins was significant for all protein pairs. Multivariate analysis showed that negative LC3B expression and absence of autophagy-related proteins expression were independently associated with poor prognosis. Conclusion. Absence of autophagy-related proteins expression is associated with poor clinical outcome in CRC, suggesting that these proteins have potential uses as novel prognostic markers.http://dx.doi.org/10.1155/2014/179586 |
| spellingShingle | Ji Hye Choi Young-Seok Cho Yoon Ho Ko Soon Uk Hong Jin Hee Park Myung Ah Lee Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma Gastroenterology Research and Practice |
| title | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma |
| title_full | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma |
| title_fullStr | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma |
| title_full_unstemmed | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma |
| title_short | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma |
| title_sort | absence of autophagy related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma |
| url | http://dx.doi.org/10.1155/2014/179586 |
| work_keys_str_mv | AT jihyechoi absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma AT youngseokcho absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma AT yoonhoko absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma AT soonukhong absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma AT jinheepark absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma AT myungahlee absenceofautophagyrelatedproteinsexpressionisassociatedwithpoorprognosisinpatientswithcolorectaladenocarcinoma |