Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise
Abstract Introduction Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exe...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.02.007 |
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| author | Camilla Steen Jensen Anja Hviid Simonsen Volkert Siersma Nina Beyer Kristian Steen Frederiksen Hanne Gottrup Kristine Hoffman Peter Høgh Ruth Frikke‐Schmidt Nanna Aue Sobol Gunhild Waldemar Lene Wermuth Steen Gregers Hasselbalch |
| author_facet | Camilla Steen Jensen Anja Hviid Simonsen Volkert Siersma Nina Beyer Kristian Steen Frederiksen Hanne Gottrup Kristine Hoffman Peter Høgh Ruth Frikke‐Schmidt Nanna Aue Sobol Gunhild Waldemar Lene Wermuth Steen Gregers Hasselbalch |
| author_sort | Camilla Steen Jensen |
| collection | DOAJ |
| description | Abstract Introduction Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers. Methods In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD. |
| format | Article |
| id | doaj-art-b63aab79c2d94f7eb58a7d05ed63613e |
| institution | Kabale University |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-b63aab79c2d94f7eb58a7d05ed63613e2025-08-20T03:30:39ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-01519910610.1016/j.trci.2019.02.007Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exerciseCamilla Steen Jensen0Anja Hviid Simonsen1Volkert Siersma2Nina Beyer3Kristian Steen Frederiksen4Hanne Gottrup5Kristine Hoffman6Peter Høgh7Ruth Frikke‐Schmidt8Nanna Aue Sobol9Gunhild Waldemar10Lene Wermuth11Steen Gregers Hasselbalch12Department of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkDepartment of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkDepartment of Public Health, Research Unit for General Practice and Section of General PracticeUniversity of CopenhagenDenmarkDepartment of Physical and Occupational TherapyInstitute of Sports Medicine, Bispebjerg and Frederiksberg Hospital, University of CopenhagenDenmarkDepartment of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkDementia Clinic, Department of NeurologyAarhus University HospitalAarhusDenmarkDepartment of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkRegional Dementia Research Centre, Department of NeurologyZealand University HospitalRoskildeDenmarkDepartment of Clinical Medicine, Faculty of Health and Medical ScienceUniversity of CopenhagenCopenhagenDenmarkDepartment of Physical and Occupational TherapyInstitute of Sports Medicine, Bispebjerg and Frederiksberg Hospital, University of CopenhagenDenmarkDepartment of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkDementia Clinic, Department of NeurologyOdense University HospitalDenmarkDepartment of Neurology, Danish Dementia Research CentreRigshospitalet Copenhagen University HospitalDenmarkAbstract Introduction Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers. Methods In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.https://doi.org/10.1016/j.trci.2019.02.007Alzheimer's diseaseExerciseAPOEGeneticIntervention |
| spellingShingle | Camilla Steen Jensen Anja Hviid Simonsen Volkert Siersma Nina Beyer Kristian Steen Frederiksen Hanne Gottrup Kristine Hoffman Peter Høgh Ruth Frikke‐Schmidt Nanna Aue Sobol Gunhild Waldemar Lene Wermuth Steen Gregers Hasselbalch Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease Exercise APOE Genetic Intervention |
| title | Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise |
| title_full | Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise |
| title_fullStr | Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise |
| title_full_unstemmed | Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise |
| title_short | Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise |
| title_sort | patients with alzheimer s disease who carry the apoe ε4 allele benefit more from physical exercise |
| topic | Alzheimer's disease Exercise APOE Genetic Intervention |
| url | https://doi.org/10.1016/j.trci.2019.02.007 |
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