Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
Advanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota. These alterations critically influence host health and have been associated with morbidity and mortality in older adults. “Inflammaging,” an age-related chronic inflammatory...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7026198 |
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| author | Anna Picca Francesca Fanelli Riccardo Calvani Giuseppina Mulè Vito Pesce Alex Sisto Cecilia Pantanelli Roberto Bernabei Francesco Landi Emanuele Marzetti |
| author_facet | Anna Picca Francesca Fanelli Riccardo Calvani Giuseppina Mulè Vito Pesce Alex Sisto Cecilia Pantanelli Roberto Bernabei Francesco Landi Emanuele Marzetti |
| author_sort | Anna Picca |
| collection | DOAJ |
| description | Advanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota. These alterations critically influence host health and have been associated with morbidity and mortality in older adults. “Inflammaging,” an age-related chronic inflammatory process, is a common trait of several conditions, including sarcopenia. Interestingly, imbalanced intestinal microbial community has been suggested to contribute to inflammaging. Changes in gut microbiota accompanying sarcopenia may be attenuated by supplementation with pre- and probiotics. Although muscle aging has been increasingly recognized as a biomarker of aging, the pathophysiology of sarcopenia is to date only partially appreciated. Due to its development in the context of the age-related inflammatory milieu, several studies favor the hypothesis of a tight connection between sarcopenia and inflammaging. However, conclusive evidence describing the signaling pathways involved has not yet been produced. Here, we review the current knowledge of the changes in intestinal microbiota that occur in advanced age with a special emphasis on findings supporting the idea of a modulation of muscle physiology through alterations in gut microbial composition and activity. |
| format | Article |
| id | doaj-art-b639f0c266704a20b25d3fbd54e7136e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b639f0c266704a20b25d3fbd54e7136e2025-02-03T01:00:24ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/70261987026198Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against SarcopeniaAnna Picca0Francesca Fanelli1Riccardo Calvani2Giuseppina Mulè3Vito Pesce4Alex Sisto5Cecilia Pantanelli6Roberto Bernabei7Francesco Landi8Emanuele Marzetti9Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyInstitute of Sciences of Food Production, National Research Council, Bari, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyInstitute of Sciences of Food Production, National Research Council, Bari, ItalyDepartment of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Bari, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, ItalyAdvanced age is characterized by several changes, one of which is the impairment of the homeostasis of intestinal microbiota. These alterations critically influence host health and have been associated with morbidity and mortality in older adults. “Inflammaging,” an age-related chronic inflammatory process, is a common trait of several conditions, including sarcopenia. Interestingly, imbalanced intestinal microbial community has been suggested to contribute to inflammaging. Changes in gut microbiota accompanying sarcopenia may be attenuated by supplementation with pre- and probiotics. Although muscle aging has been increasingly recognized as a biomarker of aging, the pathophysiology of sarcopenia is to date only partially appreciated. Due to its development in the context of the age-related inflammatory milieu, several studies favor the hypothesis of a tight connection between sarcopenia and inflammaging. However, conclusive evidence describing the signaling pathways involved has not yet been produced. Here, we review the current knowledge of the changes in intestinal microbiota that occur in advanced age with a special emphasis on findings supporting the idea of a modulation of muscle physiology through alterations in gut microbial composition and activity.http://dx.doi.org/10.1155/2018/7026198 |
| spellingShingle | Anna Picca Francesca Fanelli Riccardo Calvani Giuseppina Mulè Vito Pesce Alex Sisto Cecilia Pantanelli Roberto Bernabei Francesco Landi Emanuele Marzetti Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia Mediators of Inflammation |
| title | Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia |
| title_full | Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia |
| title_fullStr | Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia |
| title_full_unstemmed | Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia |
| title_short | Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia |
| title_sort | gut dysbiosis and muscle aging searching for novel targets against sarcopenia |
| url | http://dx.doi.org/10.1155/2018/7026198 |
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