Human iPSC-derived NK cells armed with CCL19, CCR2B, high-affinity CD16, IL-15, and NKG2D complex enhance anti-solid tumor activity

Human iPSC-derived NK cells armed with CCL19, CCR2B, high-affinity CD16, IL-15, and NKG2D complex enhance anti-solid tumor activity

Abstract Background Studies of chimeric antigen receptor (CAR)-T and -Natural killer (NK) cells have shown promising results in treating hematological malignancies. However, there are still obstacles to effectively treating solid tumors. These include the challenges of CAR-T cell homing and infiltra...

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Main Authors: Yuma Fukutani, Kenji Kurachi, Yu-suke Torisawa, Kotoko Miyata, Makoto Hayashi, Kaoru Sasaki, Kodai Saitoh, Sono Watanabe, Yudai Hasegawa, Yoichi Naritomi, Yuka Igarashi, Kumiko Goto, Yuka Sato, Noriko Uesugi, Hidetaka Murai, Tetsuya Sakurai, Toru Ozaki, Norihiro Tsuneyoshi, Masashi Yamada, Yuriko Takeno, Tomonori Hosoya, Fusako Nishigaki, Hironobu Kimura, Kouichi Tamura
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human induced pluripotent stem cell
Gene engineering
Natural killer cell
Solid tumor
Immunotherapy
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Online Access:https://doi.org/10.1186/s13287-025-04461-9
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