Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes
The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimul...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/201929 |
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| _version_ | 1849691757633077248 |
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| author | Yolanda Alvarez Isela Valera Cristina Municio Etzel Hugo Francisco Padrón Lydia Blanco Mario Rodríguez Nieves Fernández Mariano Sánchez Crespo |
| author_facet | Yolanda Alvarez Isela Valera Cristina Municio Etzel Hugo Francisco Padrón Lydia Blanco Mario Rodríguez Nieves Fernández Mariano Sánchez Crespo |
| author_sort | Yolanda Alvarez |
| collection | DOAJ |
| description | The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE2, PGD2, and several cytokines including a robust IL-10 response. Zymosan activated κB-binding activity, but inhibition of NF-κB was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE2, showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE2, thus unraveling a functional cooperation between eicosanoid production and cytokine production. |
| format | Article |
| id | doaj-art-b62d71edc4fe4400b8b2789cbebc5f5f |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b62d71edc4fe4400b8b2789cbebc5f5f2025-08-20T03:20:56ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/201929201929Eicosanoids in the Innate Immune Response: TLR and Non-TLR RoutesYolanda Alvarez0Isela Valera1Cristina Municio2Etzel Hugo3Francisco Padrón4Lydia Blanco5Mario Rodríguez6Nieves Fernández7Mariano Sánchez Crespo8Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainCentro de Hemoterapia y Hemodonación de Castilla y León, 47007-Valladolid, SpainCentro de Hemoterapia y Hemodonación de Castilla y León, 47007-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, 47003-Valladolid, SpainThe variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE2, PGD2, and several cytokines including a robust IL-10 response. Zymosan activated κB-binding activity, but inhibition of NF-κB was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE2, showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE2, thus unraveling a functional cooperation between eicosanoid production and cytokine production.http://dx.doi.org/10.1155/2010/201929 |
| spellingShingle | Yolanda Alvarez Isela Valera Cristina Municio Etzel Hugo Francisco Padrón Lydia Blanco Mario Rodríguez Nieves Fernández Mariano Sánchez Crespo Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes Mediators of Inflammation |
| title | Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes |
| title_full | Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes |
| title_fullStr | Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes |
| title_full_unstemmed | Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes |
| title_short | Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes |
| title_sort | eicosanoids in the innate immune response tlr and non tlr routes |
| url | http://dx.doi.org/10.1155/2010/201929 |
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