Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties
The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>...
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MDPI AG
2025-05-01
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| author | Mihail Lucian Birsa Laura Gabriela Sarbu |
| author_facet | Mihail Lucian Birsa Laura Gabriela Sarbu |
| author_sort | Mihail Lucian Birsa |
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| description | The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>, a structure–activity relationship study on radical scavenging properties was performed. The influence of these substituents (F, Cl, Br and H) was investigated against DPPH and ABTS<sup>+•</sup>. The results indicate that the presence of the halogen substituents induces better antioxidant properties than ascorbic acid and BHT. The highest radical scavenging activity was found in the case of morpholine carbodithioates. Regarding the ABTS<sup>+•</sup> assay, all investigated flavanones exhibited better antioxidant properties than BHT. |
| format | Article |
| id | doaj-art-b629a8a871ef4bac9576728c79f5842f |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-b629a8a871ef4bac9576728c79f5842f2025-08-20T03:46:53ZengMDPI AGMolecules1420-30492025-05-013011228010.3390/molecules30112280Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant PropertiesMihail Lucian Birsa0Laura Gabriela Sarbu1Department of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol I Blvd., 700506 Iasi, RomaniaDepartment of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol I Blvd., 700506 Iasi, RomaniaThe antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. The three frameworks that proved to be the most active ones in our previous studies were selected. By varying the nature of the substituent at the para position of flavanone ring <b>B</b>, a structure–activity relationship study on radical scavenging properties was performed. The influence of these substituents (F, Cl, Br and H) was investigated against DPPH and ABTS<sup>+•</sup>. The results indicate that the presence of the halogen substituents induces better antioxidant properties than ascorbic acid and BHT. The highest radical scavenging activity was found in the case of morpholine carbodithioates. Regarding the ABTS<sup>+•</sup> assay, all investigated flavanones exhibited better antioxidant properties than BHT.https://www.mdpi.com/1420-3049/30/11/2280antioxidantsbenzopyransdithiocarbamatesflavanonesradical enolatesbenzylic radical |
| spellingShingle | Mihail Lucian Birsa Laura Gabriela Sarbu Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties Molecules antioxidants benzopyrans dithiocarbamates flavanones radical enolates benzylic radical |
| title | Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties |
| title_full | Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties |
| title_fullStr | Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties |
| title_full_unstemmed | Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties |
| title_short | Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties |
| title_sort | iodine substituted dithiocarbamic flavanones a structure activity relationship study of their antioxidant properties |
| topic | antioxidants benzopyrans dithiocarbamates flavanones radical enolates benzylic radical |
| url | https://www.mdpi.com/1420-3049/30/11/2280 |
| work_keys_str_mv | AT mihaillucianbirsa iodinesubstituteddithiocarbamicflavanonesastructureactivityrelationshipstudyoftheirantioxidantproperties AT lauragabrielasarbu iodinesubstituteddithiocarbamicflavanonesastructureactivityrelationshipstudyoftheirantioxidantproperties |