The role of immunity in insulin resistance in patients with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related to adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1464561/full |
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| author | Qixuan Zhang Zhe Yang Xiangyang Ou Mengying Zhang Xiangyu Qin Gengxiang Wu |
| author_facet | Qixuan Zhang Zhe Yang Xiangyang Ou Mengying Zhang Xiangyu Qin Gengxiang Wu |
| author_sort | Qixuan Zhang |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related to adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While the precise pathogenesis of PCOS remains unclear, it is now recognized that genetic, endocrine, and metabolic dysregulations all contribute significantly to its onset. The immunopathogenesis of PCOS has not been extensively explored, but there is growing speculation that immune system abnormalities may play a pivotal role. This chronic inflammatory state is exacerbated by factors such as obesity and hyperinsulinemia. Therefore, this review aims to elucidate the interplay between IR in PCOS patients, the controlled immune response orchestrated by immune cells and immunomodulatory molecules, and their interactions with adipocytes, hyperandrogenemia, chronic inflammation, and metabolic homeostasis. |
| format | Article |
| id | doaj-art-b62602b7f9bd4c57adb8c55f890e725f |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-b62602b7f9bd4c57adb8c55f890e725f2025-01-22T17:06:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14645611464561The role of immunity in insulin resistance in patients with polycystic ovary syndromeQixuan Zhang0Zhe Yang1Xiangyang Ou2Mengying Zhang3Xiangyu Qin4Gengxiang Wu5Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, ChinaReproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, ChinaReproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, ChinaReproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, ChinaReproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, ChinaPolycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related to adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While the precise pathogenesis of PCOS remains unclear, it is now recognized that genetic, endocrine, and metabolic dysregulations all contribute significantly to its onset. The immunopathogenesis of PCOS has not been extensively explored, but there is growing speculation that immune system abnormalities may play a pivotal role. This chronic inflammatory state is exacerbated by factors such as obesity and hyperinsulinemia. Therefore, this review aims to elucidate the interplay between IR in PCOS patients, the controlled immune response orchestrated by immune cells and immunomodulatory molecules, and their interactions with adipocytes, hyperandrogenemia, chronic inflammation, and metabolic homeostasis.https://www.frontiersin.org/articles/10.3389/fendo.2024.1464561/fullpolycystic ovary syndromeinsulin resistanceimmune moleculesimmune cellsendocrine disorder |
| spellingShingle | Qixuan Zhang Zhe Yang Xiangyang Ou Mengying Zhang Xiangyu Qin Gengxiang Wu The role of immunity in insulin resistance in patients with polycystic ovary syndrome Frontiers in Endocrinology polycystic ovary syndrome insulin resistance immune molecules immune cells endocrine disorder |
| title | The role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| title_full | The role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| title_fullStr | The role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| title_full_unstemmed | The role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| title_short | The role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| title_sort | role of immunity in insulin resistance in patients with polycystic ovary syndrome |
| topic | polycystic ovary syndrome insulin resistance immune molecules immune cells endocrine disorder |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1464561/full |
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