The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8

The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8

Abstract Background Acute megakaryoblastic leukemia (AMKL) is a rare hematological malignancy in adults but children. Alternative splicing (AS) has been shown to affect hematological cancer progression, making splicing factors promising targets. Our research aims to investigate the efficacy of the m...

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Main Authors: Ying Yang, Zhiheng Li, Yang Yang, Peifang Xiao, Zhixu He, Zimu Zhang, Yizhen Li, Lei Shi, Xiaodong Wang, Yanfang Tao, Junjie Fan, Fenli Zhang, Chunxia Yang, Fahua Yao, Tongting Ji, Yongping Zhang, Bi Zhou, Juanjuan Yu, Ailian Guo, Zhongling Wei, Wanyan Jiao, Yumeng Wu, Yan Li, Di Wu, Yijun Wu, Li Gao, Yixin Hu, Jian Pan, Shaoyan Hu, Xiaoyan Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell & Bioscience
Subjects:
Acute megakaryoblastic leukemia
Indisulam
RBM39
Alternative splicing
ZMYND8
Online Access:https://doi.org/10.1186/s13578-025-01380-3
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