Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis

Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis

BackgroundUlcerative colitis (UC) has a complex etiology, and whether there are sex-related differences in its molecular mechanisms remains unclear. This study employed multi-omics analysis to explore sex-based differences in UC, aiming to provide support for personalized treatment.MethodsThe GSE368...

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Bibliographic Details
Main Authors: Xiaojie Fang, Jiahao Yang, Liu Yang, Yiyou Lin, Yanyan Li, Xin Yin, Xiaobing Dou, Chenyun Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
sex-specific differences
ulcerative colitis
RPS4Y1 gene
transcriptomics
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569271/full
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