Efficiency of phage therapy in humans: systematic review
Successful implementation of lytic virulent bacteriophages in clinical practice requires convincing evidence of its safety and efficacy.Design: We searched in CENTRAL, MEDLINE, Embase, and Russian-language literature databases in May 2018. Original articles must fulfill the following eligibility cri...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2019-12-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/957 |
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| author | N. V. Saperkin O. V. Kovalishena D. V. Kvashnina E. Ruizendaal R. Scholten |
| author_facet | N. V. Saperkin O. V. Kovalishena D. V. Kvashnina E. Ruizendaal R. Scholten |
| author_sort | N. V. Saperkin |
| collection | DOAJ |
| description | Successful implementation of lytic virulent bacteriophages in clinical practice requires convincing evidence of its safety and efficacy.Design: We searched in CENTRAL, MEDLINE, Embase, and Russian-language literature databases in May 2018. Original articles must fulfill the following eligibility criteria: randomized, controlled trials investigating the effects of phage therapy in people with bacterial infections; at least one patient outcome was reported. Three review authors independently selected, studies, extracted, data, and. assessed, risk of bias. We used, random-effects models for meta-analysis.Participants: adults and. children of both, sexes with bacterial infection, including multi-drug resistant variants, or individuals at risk of infection.Outcomes: recovery or resolution of infection; clinical improvement; change in number of exacerbations; recurrence of infection; quality of life; elimination or load, reduction of a pathogen in an anatomical compartment.Results: We included 13 trials (issued in 1965-2018) including 9 treatment studies and. 4 prevention studies. Overall, eight randomized, trials involved, adults. Five studies addressed skin and soft tissues infections, six studies concerned intestinal infections, one study addressed respiratory tract infection and. one study — ear infection. Across bias domains, 35-90% of trials scored, low risk of bias. Meta-analysis for adverse events attributable to phages and. for wound, healing provided us with pooled relative risks of 0.74 (95% CI 0.68;1.2) and 0.91 (95% CI0.68;1.2) respectively.Conclusions: Beneficial effect of bacteriophages can be demonstrated, and. not refuted. However, our study led. to tentative conclusions. The conduct of well-designed and sufficiently powered, trials would, facilitate registration and. wide accepting of bacteriophage treatment. |
| format | Article |
| id | doaj-art-b61fe7fc06de45fe803c0d9ffb27b1e2 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-b61fe7fc06de45fe803c0d9ffb27b1e22025-08-20T03:38:30ZrusJournal InfectologyЖурнал инфектологии2072-67322019-12-01114193010.22625/2072-6732-2019-11-4-19-30757Efficiency of phage therapy in humans: systematic reviewN. V. Saperkin0O. V. Kovalishena1D. V. Kvashnina2E. Ruizendaal3R. Scholten4Privolzhskiy Research Medical UniversityPrivolzhskiy Research Medical UniversityPrivolzhskiy Research Medical UniversityUtrecht UniversityUtrecht University, Cochrane Netherlands, University Medical CenterSuccessful implementation of lytic virulent bacteriophages in clinical practice requires convincing evidence of its safety and efficacy.Design: We searched in CENTRAL, MEDLINE, Embase, and Russian-language literature databases in May 2018. Original articles must fulfill the following eligibility criteria: randomized, controlled trials investigating the effects of phage therapy in people with bacterial infections; at least one patient outcome was reported. Three review authors independently selected, studies, extracted, data, and. assessed, risk of bias. We used, random-effects models for meta-analysis.Participants: adults and. children of both, sexes with bacterial infection, including multi-drug resistant variants, or individuals at risk of infection.Outcomes: recovery or resolution of infection; clinical improvement; change in number of exacerbations; recurrence of infection; quality of life; elimination or load, reduction of a pathogen in an anatomical compartment.Results: We included 13 trials (issued in 1965-2018) including 9 treatment studies and. 4 prevention studies. Overall, eight randomized, trials involved, adults. Five studies addressed skin and soft tissues infections, six studies concerned intestinal infections, one study addressed respiratory tract infection and. one study — ear infection. Across bias domains, 35-90% of trials scored, low risk of bias. Meta-analysis for adverse events attributable to phages and. for wound, healing provided us with pooled relative risks of 0.74 (95% CI 0.68;1.2) and 0.91 (95% CI0.68;1.2) respectively.Conclusions: Beneficial effect of bacteriophages can be demonstrated, and. not refuted. However, our study led. to tentative conclusions. The conduct of well-designed and sufficiently powered, trials would, facilitate registration and. wide accepting of bacteriophage treatment.https://journal.niidi.ru/jofin/article/view/957bacteriophagetherapyprophylaxisbacterial infectionsystematic reviewmeta-analysisbiaswoundadverse event |
| spellingShingle | N. V. Saperkin O. V. Kovalishena D. V. Kvashnina E. Ruizendaal R. Scholten Efficiency of phage therapy in humans: systematic review Журнал инфектологии bacteriophage therapy prophylaxis bacterial infection systematic review meta-analysis bias wound adverse event |
| title | Efficiency of phage therapy in humans: systematic review |
| title_full | Efficiency of phage therapy in humans: systematic review |
| title_fullStr | Efficiency of phage therapy in humans: systematic review |
| title_full_unstemmed | Efficiency of phage therapy in humans: systematic review |
| title_short | Efficiency of phage therapy in humans: systematic review |
| title_sort | efficiency of phage therapy in humans systematic review |
| topic | bacteriophage therapy prophylaxis bacterial infection systematic review meta-analysis bias wound adverse event |
| url | https://journal.niidi.ru/jofin/article/view/957 |
| work_keys_str_mv | AT nvsaperkin efficiencyofphagetherapyinhumanssystematicreview AT ovkovalishena efficiencyofphagetherapyinhumanssystematicreview AT dvkvashnina efficiencyofphagetherapyinhumanssystematicreview AT eruizendaal efficiencyofphagetherapyinhumanssystematicreview AT rscholten efficiencyofphagetherapyinhumanssystematicreview |