Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target

Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target

Abstract We identified a subset of patients with colorectal cancer (CRC) enriched with “collagen-TAMs,” designated the CM class, using large integrated colon cancer transcriptome and single-cell transcriptome datasets. This classification system could be used as an extension of the traditional CMS c...

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Bibliographic Details
Main Authors: Shuwen Chen, Zhaoyan Jiang, Wanxuan Song, Chuqiao Lu, Yanbing Lin, Shiyao Xu, Kunxin Xie, Li Wan, Xiaoqin Yuan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Gastroenterology
Subjects:
Colorectal cancer
Immunotherapy
Classification system
THBS2
Online Access:https://doi.org/10.1186/s12876-025-03918-8
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