Modern options of prokinetics in gastroesophageal reflux disease treatment
Aim of the lecture. To present modern approaches to prokinetic treatment at gastroesophageal reflux disease (GERD) to gastroenterologists. Summary. GERD belongs to acid-related diseases, because detrimental action of hydrochloric acid on esophageal mucosa plays major role in its pathogenesis. Howeve...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/219 |
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| _version_ | 1823860305126490112 |
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| author | A. A. Sheptulin A. A. Kurbatova S. A. Baranov |
| author_facet | A. A. Sheptulin A. A. Kurbatova S. A. Baranov |
| author_sort | A. A. Sheptulin |
| collection | DOAJ |
| description | Aim of the lecture. To present modern approaches to prokinetic treatment at gastroesophageal reflux disease (GERD) to gastroenterologists. Summary. GERD belongs to acid-related diseases, because detrimental action of hydrochloric acid on esophageal mucosa plays major role in its pathogenesis. However esophageal and stomach motility disorders, e.g.: increase in frequency of transient lower esophageal sphincter relaxations, decrease of esophageal clearance and increase of intragastric pressure play important role in GERD development as well. These factors along with the not uncommon resistance of GERD patients to the proton pump inhibitors (PPI) caused by nonacidic refluxes require prokinetic administration. Most commonly prokinetics are prescribed as supplemental to PPI treatment. At the present time the optimal prokinetic drug, with proved efficacy at GERD and other diseases associated to gastrointestinal dysmotility is itopride hydrochloride (Ganaton®). Conclusion. Taken into account important role of esophageal and stomach dysmotility in GERD pathogenesis, prokinetics can be recommended for comprehensive disease treatment, especially at PPI inefficacy. |
| format | Article |
| id | doaj-art-b6186ec985a24d7790204001c3275a12 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b6186ec985a24d7790204001c3275a122025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01281717710.22416/1382-4376-2018-28-1-71-77219Modern options of prokinetics in gastroesophageal reflux disease treatmentA. A. Sheptulin0A. A. Kurbatova1S. A. Baranov2Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityAim of the lecture. To present modern approaches to prokinetic treatment at gastroesophageal reflux disease (GERD) to gastroenterologists. Summary. GERD belongs to acid-related diseases, because detrimental action of hydrochloric acid on esophageal mucosa plays major role in its pathogenesis. However esophageal and stomach motility disorders, e.g.: increase in frequency of transient lower esophageal sphincter relaxations, decrease of esophageal clearance and increase of intragastric pressure play important role in GERD development as well. These factors along with the not uncommon resistance of GERD patients to the proton pump inhibitors (PPI) caused by nonacidic refluxes require prokinetic administration. Most commonly prokinetics are prescribed as supplemental to PPI treatment. At the present time the optimal prokinetic drug, with proved efficacy at GERD and other diseases associated to gastrointestinal dysmotility is itopride hydrochloride (Ganaton®). Conclusion. Taken into account important role of esophageal and stomach dysmotility in GERD pathogenesis, prokinetics can be recommended for comprehensive disease treatment, especially at PPI inefficacy.https://www.gastro-j.ru/jour/article/view/219гастроэзофагеальная рефлюксная болезньнарушения моторики пищевода и желудкапрокинетики |
| spellingShingle | A. A. Sheptulin A. A. Kurbatova S. A. Baranov Modern options of prokinetics in gastroesophageal reflux disease treatment Российский журнал гастроэнтерологии, гепатологии, колопроктологии гастроэзофагеальная рефлюксная болезнь нарушения моторики пищевода и желудка прокинетики |
| title | Modern options of prokinetics in gastroesophageal reflux disease treatment |
| title_full | Modern options of prokinetics in gastroesophageal reflux disease treatment |
| title_fullStr | Modern options of prokinetics in gastroesophageal reflux disease treatment |
| title_full_unstemmed | Modern options of prokinetics in gastroesophageal reflux disease treatment |
| title_short | Modern options of prokinetics in gastroesophageal reflux disease treatment |
| title_sort | modern options of prokinetics in gastroesophageal reflux disease treatment |
| topic | гастроэзофагеальная рефлюксная болезнь нарушения моторики пищевода и желудка прокинетики |
| url | https://www.gastro-j.ru/jour/article/view/219 |
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