Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy
Up to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resistant nonlesional extratemporal lobe epilepsy (ETLE) pose the...
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| Format: | Article |
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SAGE Publishing
2021-01-01
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| Series: | Molecular Imaging |
| Online Access: | http://dx.doi.org/10.1155/2021/6614356 |
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| author | Ahmed Yassin Khalid El-Salem Abdel-Hameed Al-Mistarehi Aiman Momani Anas M. Zein Alaabdin Palak Shah James Michael Mountz Anto I. Bagić |
| author_facet | Ahmed Yassin Khalid El-Salem Abdel-Hameed Al-Mistarehi Aiman Momani Anas M. Zein Alaabdin Palak Shah James Michael Mountz Anto I. Bagić |
| author_sort | Ahmed Yassin |
| collection | DOAJ |
| description | Up to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resistant nonlesional extratemporal lobe epilepsy (ETLE) pose the biggest challenge in localizing the SOZ and require multiple noninvasive diagnostic investigations before planning the intracranial monitoring (ICM) or direct resection. Ictal Single Photon Emission Computed Tomography (i-SPECT) is a unique functional diagnostic tool that assesses the SOZ using the localized hyperperfusion that occurs early in the seizure. Subtraction ictal SPECT coregistered to MRI (SISCOM), statistical ictal SPECT coregistered to MRI (STATISCOM), and PET interictal subtracted ictal SPECT coregistered with MRI (PISCOM) are innovative SPECT methods for the determination of the SOZ. This article comprehensively reviews SPECT and sheds light on its vital role in the presurgical evaluation of the nonlesional extratemporal DRE. |
| format | Article |
| id | doaj-art-b617ded7469449baac1324ce1d24109a |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-b617ded7469449baac1324ce1d24109a2025-01-02T22:37:50ZengSAGE PublishingMolecular Imaging1536-01212021-01-01202110.1155/2021/66143566614356Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant EpilepsyAhmed Yassin0Khalid El-Salem1Abdel-Hameed Al-Mistarehi2Aiman Momani3Anas M. Zein Alaabdin4Palak Shah5James Michael Mountz6Anto I. Bagić7Division of Neurology, Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanDivision of Neurology, Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanDepartment of Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanDivision of Neurology, Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanDepartment of Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanMinnesota Epilepsy Group PA, St Paul, Minnesota, USADivision of Nuclear Medicine, Department of Radiology, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania, USAUniversity of Pittsburgh Comprehensive Epilepsy Center (UPCEC), Pittsburgh, USAUp to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resistant nonlesional extratemporal lobe epilepsy (ETLE) pose the biggest challenge in localizing the SOZ and require multiple noninvasive diagnostic investigations before planning the intracranial monitoring (ICM) or direct resection. Ictal Single Photon Emission Computed Tomography (i-SPECT) is a unique functional diagnostic tool that assesses the SOZ using the localized hyperperfusion that occurs early in the seizure. Subtraction ictal SPECT coregistered to MRI (SISCOM), statistical ictal SPECT coregistered to MRI (STATISCOM), and PET interictal subtracted ictal SPECT coregistered with MRI (PISCOM) are innovative SPECT methods for the determination of the SOZ. This article comprehensively reviews SPECT and sheds light on its vital role in the presurgical evaluation of the nonlesional extratemporal DRE.http://dx.doi.org/10.1155/2021/6614356 |
| spellingShingle | Ahmed Yassin Khalid El-Salem Abdel-Hameed Al-Mistarehi Aiman Momani Anas M. Zein Alaabdin Palak Shah James Michael Mountz Anto I. Bagić Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy Molecular Imaging |
| title | Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy |
| title_full | Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy |
| title_fullStr | Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy |
| title_full_unstemmed | Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy |
| title_short | Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy |
| title_sort | use of innovative spect techniques in the presurgical evaluation of patients with nonlesional extratemporal drug resistant epilepsy |
| url | http://dx.doi.org/10.1155/2021/6614356 |
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