Outcome of Radioiodine Therapy in a West African Population
Hyperthyroidism continues to be a pressing public health concern in West Africa. Its prevalence in Africa has been quoted as 1.2%-9.9%, with Graves' disease as its most common cause. Radioiodine-131 (RAI) therapy of hyperthyroidism recently commenced in two government hospitals in Ghana and Nig...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-01-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167585 |
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| author | Yetunde Onimode Alfred Ankrah Kayode Adedapo |
| author_facet | Yetunde Onimode Alfred Ankrah Kayode Adedapo |
| author_sort | Yetunde Onimode |
| collection | DOAJ |
| description | Hyperthyroidism continues to be a pressing public health concern in West Africa. Its prevalence in Africa has been quoted as 1.2%-9.9%, with Graves' disease as its most common cause. Radioiodine-131 (RAI) therapy of hyperthyroidism recently commenced in two government hospitals in Ghana and Nigeria. This is a retrospective analysis of consecutive patients treated with RAI for primary hyperthyroidism at the National Centre for Radiotherapy and Nuclear Medicine (NCRNM) from 2008-2013, and in the University College Hospital (UCH) from 2006-2013. Cure was defined as euthyroidism or hypothyroidism occurring at 6 months post-RAI. Data were analysed using SPSS version 21 and Epi Info version, categorical data were evaluated with the Chi-square test and Fisher's exact test. 94 patients were studied, aged 20-74 years; 78 were females, and 16 were males. 38 were Ghanaian and 56 Nigerian. The presence of thyroid-associated ophthalmopathy (TAO) made cure less likely (χ2 P = 0.006, odds ratio = 0.118; 95% confidence interval, 0.027-0.518). Other factors assessed proved to be insignificant. Our findings suggest that hyperthyroid patients with TAO will benefit from a higher RAI dose than their counterparts without TAO. |
| format | Article |
| id | doaj-art-b616dcbf0dc8459ab4baab02088c196c |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-b616dcbf0dc8459ab4baab02088c196c2025-08-20T02:00:17ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122016-01-011501242910.4103/1450-1147.167585Outcome of Radioiodine Therapy in a West African PopulationYetunde Onimode0Alfred Ankrah1Kayode Adedapo2Department of Nuclear Medicine, University College Hospital, Ibadan, Oyo State, NigeriaDepartment of Nuclear Medicine, National Centre for Radiotherapy and Nuclear Medicine, Korle Bu Hospital, Accra, GhanaDepartment of Nuclear Medicine, University College Hospital, Ibadan, Oyo State, NigeriaHyperthyroidism continues to be a pressing public health concern in West Africa. Its prevalence in Africa has been quoted as 1.2%-9.9%, with Graves' disease as its most common cause. Radioiodine-131 (RAI) therapy of hyperthyroidism recently commenced in two government hospitals in Ghana and Nigeria. This is a retrospective analysis of consecutive patients treated with RAI for primary hyperthyroidism at the National Centre for Radiotherapy and Nuclear Medicine (NCRNM) from 2008-2013, and in the University College Hospital (UCH) from 2006-2013. Cure was defined as euthyroidism or hypothyroidism occurring at 6 months post-RAI. Data were analysed using SPSS version 21 and Epi Info version, categorical data were evaluated with the Chi-square test and Fisher's exact test. 94 patients were studied, aged 20-74 years; 78 were females, and 16 were males. 38 were Ghanaian and 56 Nigerian. The presence of thyroid-associated ophthalmopathy (TAO) made cure less likely (χ2 P = 0.006, odds ratio = 0.118; 95% confidence interval, 0.027-0.518). Other factors assessed proved to be insignificant. Our findings suggest that hyperthyroid patients with TAO will benefit from a higher RAI dose than their counterparts without TAO.http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167585goitrehyperthyroidismnuclear medicineradioiodinewest africa |
| spellingShingle | Yetunde Onimode Alfred Ankrah Kayode Adedapo Outcome of Radioiodine Therapy in a West African Population World Journal of Nuclear Medicine goitre hyperthyroidism nuclear medicine radioiodine west africa |
| title | Outcome of Radioiodine Therapy in a West African Population |
| title_full | Outcome of Radioiodine Therapy in a West African Population |
| title_fullStr | Outcome of Radioiodine Therapy in a West African Population |
| title_full_unstemmed | Outcome of Radioiodine Therapy in a West African Population |
| title_short | Outcome of Radioiodine Therapy in a West African Population |
| title_sort | outcome of radioiodine therapy in a west african population |
| topic | goitre hyperthyroidism nuclear medicine radioiodine west africa |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.167585 |
| work_keys_str_mv | AT yetundeonimode outcomeofradioiodinetherapyinawestafricanpopulation AT alfredankrah outcomeofradioiodinetherapyinawestafricanpopulation AT kayodeadedapo outcomeofradioiodinetherapyinawestafricanpopulation |