SENP5 drives breast cancer progression through deSUMOYlation of CDK1

SENP5 drives breast cancer progression through deSUMOYlation of CDK1

Abstract Background Breast cancer (BRCA) remains a significant global health concern, with the need for novel therapeutic targets to improve patient outcomes. The role of the SENP family of de-SUMOylating enzymes in BRCA is not yet fully understood. Methods The expression and prognostic value of SEN...

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Bibliographic Details
Main Authors: Cui Chen, Hanming Yao, Haiqing Jie, Zhenkang Liang, Yuxuan Zhang, Xinyun Wen, Jinze Zhao, Huiping Xiong, Zongheng Zheng, Juekun Wu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Breast cancer
SENP5
CDK1
SUMOylation
Cell cycle
Online Access:https://doi.org/10.1186/s13058-025-02054-1
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