VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Abstract Semliki Forest virus (SFV) is a neuropathogenic alphavirus which is of interest both as a model neurotropic alphavirus and as an oncolytic virus with proven potency in preclinical cancer models. In laboratory mice, peripherally administered SFV infiltrates the central nervous system (CNS) a...

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Main Authors: Miika Martikainen, Roberta Lugano, Ilkka Pietilä, Sofie Brosch, Camille Cabrolier, Aishwarya Sivaramakrishnan, Mohanraj Ramachandran, Di Yu, Anna Dimberg, Magnus Essand
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55493-3
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