Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

Malignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and di...

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Main Authors: Tiphaine de Foucher, Hélène Roussel, Mikael Hivelin, Léa Rossi, Caroline Cornou, Anne-Sophie Bats, Myriam Deloménie, Fabrice Lécuru, Charlotte Ngô
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2017/8963013
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author Tiphaine de Foucher
Hélène Roussel
Mikael Hivelin
Léa Rossi
Caroline Cornou
Anne-Sophie Bats
Myriam Deloménie
Fabrice Lécuru
Charlotte Ngô
author_facet Tiphaine de Foucher
Hélène Roussel
Mikael Hivelin
Léa Rossi
Caroline Cornou
Anne-Sophie Bats
Myriam Deloménie
Fabrice Lécuru
Charlotte Ngô
author_sort Tiphaine de Foucher
collection DOAJ
description Malignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and distant, hematogenous, mostly to the lungs, bones, and brain. Distant metastasis (DM) can be synchronous or appear months to years after the diagnosis and initial management. The current report describes the case of a 57-year-old woman presenting with a giant/neglected MPT of the breast, with no DM at initial staging, treated by radical modified mastectomy. Motor disorders due to medullar compression by a paravertebral mass appeared at short follow-up, also treated surgically. The patient died from several DM of rapid evolution. To our knowledge, this is the only case described of MPT with metastases to soft tissue causing medullar compression. We present a literature review on unusual metastatic localizations of MPT.
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institution Kabale University
issn 2090-6684
2090-6692
language English
publishDate 2017-01-01
publisher Wiley
record_format Article
series Case Reports in Obstetrics and Gynecology
spelling doaj-art-b60f4d9b9c1b4bdaadf36f06c5ef04022025-02-03T01:27:54ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922017-01-01201710.1155/2017/89630138963013Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature ReviewTiphaine de Foucher0Hélène Roussel1Mikael Hivelin2Léa Rossi3Caroline Cornou4Anne-Sophie Bats5Myriam Deloménie6Fabrice Lécuru7Charlotte Ngô8Department of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Pathology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Plastic and Reconstructive Surgery, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceDepartment of Breast and Gynecological Surgical Oncology, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceMalignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and distant, hematogenous, mostly to the lungs, bones, and brain. Distant metastasis (DM) can be synchronous or appear months to years after the diagnosis and initial management. The current report describes the case of a 57-year-old woman presenting with a giant/neglected MPT of the breast, with no DM at initial staging, treated by radical modified mastectomy. Motor disorders due to medullar compression by a paravertebral mass appeared at short follow-up, also treated surgically. The patient died from several DM of rapid evolution. To our knowledge, this is the only case described of MPT with metastases to soft tissue causing medullar compression. We present a literature review on unusual metastatic localizations of MPT.http://dx.doi.org/10.1155/2017/8963013
spellingShingle Tiphaine de Foucher
Hélène Roussel
Mikael Hivelin
Léa Rossi
Caroline Cornou
Anne-Sophie Bats
Myriam Deloménie
Fabrice Lécuru
Charlotte Ngô
Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
Case Reports in Obstetrics and Gynecology
title Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
title_full Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
title_fullStr Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
title_full_unstemmed Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
title_short Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review
title_sort atypical distant metastasis of breast malignant phyllodes tumors a case report and literature review
url http://dx.doi.org/10.1155/2017/8963013
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