RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches

RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, posing significant treatment challenges, particularly in its metastatic form (mCRC). This review comprehensively examines the pivotal role of RAS mutations, specifically KRAS and NRAS, which are detected in approxi...

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Bibliographic Details
Main Authors: Osman Sütcüoğlu, Hasan Çağrı Yıldırım, Elvina Almuradova, Damla Günenç, Şuayib Yalçın
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Medicina
Subjects:
colon cancer
RAS mutation
molecular oncology
survival
Online Access:https://www.mdpi.com/1648-9144/61/7/1202
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