Case report: A rare case of oral sebaceous carcinoma in the upper lip
Sebaceous carcinoma (SC) is a rare aggressive malignant tumor that originates in the adnexal epithelium of the sebaceous gland. While occurrences on the lips are extremely uncommon, there have been a few reported cases in the literature. Our case involves a 47-year-old smoker male who presented with...
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| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Pathology and Oncology Research |
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| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2024.1611968/full |
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| author | Yousef Katib Yousef Katib Murad Essatari |
| author_facet | Yousef Katib Yousef Katib Murad Essatari |
| author_sort | Yousef Katib |
| collection | DOAJ |
| description | Sebaceous carcinoma (SC) is a rare aggressive malignant tumor that originates in the adnexal epithelium of the sebaceous gland. While occurrences on the lips are extremely uncommon, there have been a few reported cases in the literature. Our case involves a 47-year-old smoker male who presented with a painless, non-mobile lesion on his upper lip that had been present for 12 months. Upon clinical examination, an ulcerated, exophytic, and irregularly shaped mass was observed on the upper lip. No other intraoral lesions were found. An incisional biopsy was performed, revealing a malignant tumor with a nodular pattern consisting of basaloid cells with obvious sebaceous differentiations and frequent mitoses. The neoplastic cells tested positive for broad-spectrum cytokeratin (AE1-AE3), epithelial membrane antigen (EMA), and P53, while testing negative for S-100 and carcinoembryonic antigen (CEA). Based on these results, a diagnosis of SC of the upper lip was made. This case report and review aimed to describe the histogenesis, unique clinicopathological features, and current treatment options for SC. |
| format | Article |
| id | doaj-art-b60cd02c8a6944d5ab2ac862ed39c4a2 |
| institution | DOAJ |
| issn | 1532-2807 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj-art-b60cd02c8a6944d5ab2ac862ed39c4a22025-08-20T02:49:53ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072024-11-013010.3389/pore.2024.16119681611968Case report: A rare case of oral sebaceous carcinoma in the upper lipYousef Katib0Yousef Katib1Murad Essatari2College of Medicine, Taibah University, Madinah, Saudi ArabiaKing Abdulaziz Medical City, Prince Noorah Oncology Center, Jeddah, Saudi ArabiaKing Abdulaziz Medical City, Prince Noorah Oncology Center, Jeddah, Saudi ArabiaSebaceous carcinoma (SC) is a rare aggressive malignant tumor that originates in the adnexal epithelium of the sebaceous gland. While occurrences on the lips are extremely uncommon, there have been a few reported cases in the literature. Our case involves a 47-year-old smoker male who presented with a painless, non-mobile lesion on his upper lip that had been present for 12 months. Upon clinical examination, an ulcerated, exophytic, and irregularly shaped mass was observed on the upper lip. No other intraoral lesions were found. An incisional biopsy was performed, revealing a malignant tumor with a nodular pattern consisting of basaloid cells with obvious sebaceous differentiations and frequent mitoses. The neoplastic cells tested positive for broad-spectrum cytokeratin (AE1-AE3), epithelial membrane antigen (EMA), and P53, while testing negative for S-100 and carcinoembryonic antigen (CEA). Based on these results, a diagnosis of SC of the upper lip was made. This case report and review aimed to describe the histogenesis, unique clinicopathological features, and current treatment options for SC.https://www.por-journal.com/articles/10.3389/pore.2024.1611968/fullsebaceous carcinomaoral cavitylipimmunohistochemistrytreatmentoral cavity |
| spellingShingle | Yousef Katib Yousef Katib Murad Essatari Case report: A rare case of oral sebaceous carcinoma in the upper lip Pathology and Oncology Research sebaceous carcinoma oral cavity lip immunohistochemistry treatment oral cavity |
| title | Case report: A rare case of oral sebaceous carcinoma in the upper lip |
| title_full | Case report: A rare case of oral sebaceous carcinoma in the upper lip |
| title_fullStr | Case report: A rare case of oral sebaceous carcinoma in the upper lip |
| title_full_unstemmed | Case report: A rare case of oral sebaceous carcinoma in the upper lip |
| title_short | Case report: A rare case of oral sebaceous carcinoma in the upper lip |
| title_sort | case report a rare case of oral sebaceous carcinoma in the upper lip |
| topic | sebaceous carcinoma oral cavity lip immunohistochemistry treatment oral cavity |
| url | https://www.por-journal.com/articles/10.3389/pore.2024.1611968/full |
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