Targeting KRAS Sensitizes Ferroptosis by Coordinately Regulating the TCA Cycle and Nrf2‐SLC7A11‐GPX4 Signaling in Hepatocellular Carcinoma

Targeting KRAS Sensitizes Ferroptosis by Coordinately Regulating the TCA Cycle and Nrf2‐SLC7A11‐GPX4 Signaling in Hepatocellular Carcinoma

ABSTRACT Oncogenic KRAS, a notorious driver of cancer progression, remains a therapeutic challenge. In hepatocellular carcinoma (HCC), KRAS overexpression correlates with tumor aggressiveness. Here, we demonstrate that NSC48160 induces HCC cell death by suppressing KRAS expression. Metabolomic profi...

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Bibliographic Details
Main Authors: Jiaxin Zhang, Zuojia Liu, Wenjing Zhao, Chang Li, Fei Liu, Jin Wang
Format: Article
Language:English
Published: Wiley-VCH 2025-06-01
Series:Smart Medicine
Subjects:
ferroptosis
hepatocellular carcinoma
KRAS
metabolomics
NSC48160
Online Access:https://doi.org/10.1002/smmd.70005
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