Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy
Objective: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. Methods: The cohorts included a total of 528 patients from the Surveillance,...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221438822030031X |
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| author | Mengzhu Liu Kun Jin Shi Qiu Pengyong Xu Mingming Zhang Wufeng Cai Xiaonan Zheng Lu Yang Qiang Wei |
| author_facet | Mengzhu Liu Kun Jin Shi Qiu Pengyong Xu Mingming Zhang Wufeng Cai Xiaonan Zheng Lu Yang Qiang Wei |
| author_sort | Mengzhu Liu |
| collection | DOAJ |
| description | Objective: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. Methods: The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented. Results: Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13–0.47 and HR=0.26, 95% CI 0.17–0.40, respectively; after matching: HR=0.18, 95% CI 0.04–0.82 and HR=0.28, 95% CI 0.11–0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06–0.57, p<0.01 and HR=0.17, 95% CI 0.06–0.54, p<0.01). Conclusion: Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP. |
| format | Article |
| id | doaj-art-b60bbacdc80b4e12b56fc28600766715 |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-b60bbacdc80b4e12b56fc286007667152025-08-20T03:52:10ZengElsevierAsian Journal of Urology2214-38822021-04-018222723410.1016/j.ajur.2020.05.005Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapyMengzhu Liu0Kun Jin1Shi Qiu2Pengyong Xu3Mingming Zhang4Wufeng Cai5Xiaonan Zheng6Lu Yang7Qiang Wei8Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China; Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, the First People's Hospital, Yantai, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China; Corresponding author.Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China; Corresponding author.Objective: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. Methods: The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented. Results: Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13–0.47 and HR=0.26, 95% CI 0.17–0.40, respectively; after matching: HR=0.18, 95% CI 0.04–0.82 and HR=0.28, 95% CI 0.11–0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06–0.57, p<0.01 and HR=0.17, 95% CI 0.06–0.54, p<0.01). Conclusion: Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP.http://www.sciencedirect.com/science/article/pii/S221438822030031XDuctal adenocarcinoma of the prostateCancer specific mortalityOverall mortalityRadical prostatectomyRadiotherapy |
| spellingShingle | Mengzhu Liu Kun Jin Shi Qiu Pengyong Xu Mingming Zhang Wufeng Cai Xiaonan Zheng Lu Yang Qiang Wei Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy Asian Journal of Urology Ductal adenocarcinoma of the prostate Cancer specific mortality Overall mortality Radical prostatectomy Radiotherapy |
| title | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| title_full | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| title_fullStr | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| title_full_unstemmed | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| title_short | Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| title_sort | oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy |
| topic | Ductal adenocarcinoma of the prostate Cancer specific mortality Overall mortality Radical prostatectomy Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S221438822030031X |
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